
"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This study is for men having regular monitoring for prostate cancer contained within the prostate gland (localised prostate cancer).
Prostate cancer can grow so slowly that it never causes any symptoms. So, some men with localised prostate cancer have regular monitoring. This is called active surveillance. It means you don’t have treatment straight away. Your doctor keeps a close eye on you to check for any signs that the cancer is growing. If it does, then you and your doctor will decide which treatment is best for you.
Some newer research suggests that having aspirin and vitamin D3 can stop cancer from growing and changing. So researchers want to find out more. In this study, they want to see how useful these drugs are in men having active surveillance.
This is a feasibility study. This helps the study team to check the design before running a larger trial. The aims of this study are to find out:
The following bullet points list the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you.
You might be able to join this study if all of the following apply. You
You cannot join this study if any of these apply. You
Cancer related
Medical conditions
Other
This feasibility study is based in the UK. The researchers need 102 men to take part.
It is a randomised study. You are put into 1 of 6 groups. Neither you nor your doctor will be able to decide which group you are in. And neither of you will know which group you are in either. This is called a double blind study. You have 1 of the following:
Aspirin and dummy aspirin are tablets. You take aspirin or the dummy drug once a day, everyday.
Vitamin D3 and dummy vitamin D3 are an oily liquid. You have a few drops once a day, everyday. You can take them on their own, soaked in some bread or in a small amount of fruit juice.
You have treatment for up to a year and a half.
You see a doctor and have some tests before you can take part. These include:
You see the study team every 3 months for a check up. At each visit you have some blood tests.
A year after you join the study:
Aspirin is a commonly used drug with very few side effects. The most serious side effect of aspirin is a slightly increased risk of bleeding.
Other possible side effects include:
Very rarely, people have an allergic reaction to aspirin. And it can sometimes make asthma worse.
The study team recommend that while you are taking part in the study you do not take any extra aspirin or NSAIDS such as ibuprofen.
Side effects from vitamin D3 are very rare. Possible side effects include:
The study team will talk to you about all the possible risks before you agree to join.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Mr Greg Shaw
Barts and the London Charity
Experimental Cancer Medicine Centre (ECMC)
Queen Mary University of London
Freephone 0808 800 4040
"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”