Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.
A study of a vaccine for people with cancer (ACIT-1)
This study is looking at using a vaccine called allogeneic cell immunotherapy 1 (ACIT-1) vaccine for people with cancer.
It is open to people with any type of cancer who are going to a cancer clinic at the Royal Liverpool and Broadgreen University Hospital.
More about this trial
- how safe the vaccine is
- what the side effects are
- how well people cope with having the vaccine
- if the ACIT-1 vaccine can get your immune system to recognise and kill cancer cells
- what is the best dose or range of dose to give
Who can enter
- you have cancer
- all your other blood results are satisfactory
- you are up and about, can look after yourself but may not be able to work (performance score 0, 1 or 2)
- you have a normal heart trace (ECG)
- you are willing to use reliable contraception during the study and for 3 months afterwards if you or your partner could become pregnant
- you are at least 18 years old
- have had cancer treatment in the past 28 days. You might be able to join if you are having standard chemotherapy treatment for cancer of the pancreas or a blood cancer
- are taking medication that damps down your immune system in particular steroids with a dose of 10mg or more a day
- have HIV, hepatitis B, hepatitis C or syphilis
- have another active infection
- have taken an experimental drug as part of a clinical trial in past 28 days
- have had another vaccination in the past 4 weeks
- have had antibody treatment in the past 3 months
- have had major surgery within 2 weeks of being considered for this study
- are scheduled to have a procedure, such as elective surgery, that means you will have an anaesthetic during the time you are in the study
- have had a donor stem cell or bone marrow transplant (an allogeneic transplant)
- have an active autoimmune disease
- have had a serious allergic reaction to any drug
- have a serious medical condition such as congestive heart failure, angina or an abnormal heartbeat, that isn’t controlled by medication
- have any other medical or mental health condition that your doctor or study team think could affect you taking part
- when you agree to join, to make sure you are able to take part
- before your 1st treatment
- before your 2nd treatment
- 4 weeks after the 2nd treatment
- 12 weeks later
- how well the vaccines are working
- to see if the 2nd vaccine treatment has boosted the 1st treatment and helped it to continue to work
- more about your cancer and how to treat it
- a physical examination
- blood tests
- heart trace (ECG)
- CT scan
After injecting the ACIT-1 vaccine just under the skin you will have a small lump. This will gradually go down after a few days.
The ACIT-1 vaccine is a new treatment and there may be side effects we don’t know about yet. The side effects reported so far are similar to other vaccines used for infectious diseases.
They are redness, swelling, mild pain or itching where you had the injection.
On the very rare occasion a small blister might occur.
You might also have flu like symptoms such as feeling unwell or a high temperature (fever) for a few days after.
How to join a clinical trial
Professor Daniel Palmer
Royal Liverpool and Broadgreen University Hospital
Clatterbridge Cancer Centre NHS Foundation Trust
University of Liverpool
Cancer Research UK
National Institute for Health Research (NIHR)
Cancer Vaccines Charitable Trust