A study measuring the levels of chemotherapy in the blood (NCCPG TDM 2018)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

All cancer types
Children's cancers





In this study researchers measure the amount of chemotherapy drugs in the blood. They want to see how different levels of the drugs affect how well they work and the side effects.

More about this trial

We know from previous research there are differences in how well people’s bodies get rid of chemotherapy drugs. It’s possible to measure the levels of chemotherapy in the blood from a blood sample. This tells doctors how well your body gets rid of the chemotherapy. 

Knowing this can help the doctor adjust the dose of chemotherapy that some people need. 

In this study researchers will use some of these blood samples and look at medical records. They want to find out if different levels of chemotherapy affect: 

  • how well the chemotherapy works
  • what the side effects are  

You may not get any benefit from joining the trial but the information gained might help people in in the future. 

Who can enter

The following bullet points list the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you. 

Who can take part

You may be able to join this study if all of the following apply. 

  • You have cancer.
  • You are having chemotherapy but not as a standard dose.   
  • Your doctor is monitoring your chemotherapy treatment very closely.
  • You are 17 years old or younger.

Trial design

The study team expect about 300 children, teenagers and young people to join this study. 

As part of your care you have regular blood samples taken. They will take extra samples when you have blood tests as part of your usual care. They will send these samples to the Newcastle University Centre for Cancer for analysis. After this anything remaining of the sample is stored until the end of the study. 

At the end of the study they will move these remaining blood samples to the Children’s Cancer and Leukaemia Group (GCLG) for use in future research. You don’t have to agree to this if you don’t want to. You can still take part in the study. 

As part of the study the team will ask your doctor to send them your medical details before and after your treatment.

Hospital visits

There are no extra hospital visits if you take part in the study. 

The study team will continue to follow you through your medical records for 3 years.  

Side effects

There are no side effects if you take part in this study. 

We have information about the side effects of chemotherapy

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Deborah Tweedle

Supported by

National Institute for Health Research (NIHR)
Newcastle University

If you have questions about the trial please contact our cancer information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Last reviewed:

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