A study looking at using everolimus for advanced kidney cancer

Cancer type:

Kidney cancer
Renal cell cancer




Phase 2

This study looked at using everolimus for kidney cancer that has spread to another part of the body.

It was for people who were having surgery to remove the kidney as part of their treatment. 

Cancer Research UK supported this trial.

More about this trial

When this trial was done, doctors could treat advanced kidney cancer with surgery or a targeted cancer drug. Open a glossary item 

Everolimus is a type of targeted drug. At the time of the trial, doctors used everolimus advanced kidney cancer that has come back. It works by stopping a protein called mTOR from working properly and so may stop the cancer from growing or slow it down.

The researchers in this trial thought that everolimus before surgery may help people with advanced kidney cancer.

The main aims of this study were to find out:

  • how safe it is to give everolimus to people before and after having surgery to remove the kidney
  • what the side effects are
  • how well everolimus works after surgery for people with advanced kidney cancer

Summary of results

This trial closed earlier than planned. This was because there were better available treatments for kidney cancer that had come back. 

Only 7 people joined the trial before it closed. So there wasn't enough information to analyse and the trial didn't produce any results. 

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr James Larkin

Supported by

Cancer Research UK
NIHR Clinical Research Network: Cancer
The Royal Marsden NHS Foundation Trust

Other information

This is Cancer Research UK trial number CRUKE/10/047.

If you have questions about the trial please contact our cancer information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Last reviewed:

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