"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”
A study looking at thinking, memory and concentration problems in men having hormone treatment for prostate cancer (CogCan)
Problems with thinking, concentration and memory are called cognitive problems.
This study is for men who are going to have treatment to lower the levels of the male sex hormone
More about this trial
One of the possible side effects of hormone therapy is problems with thinking. You may also have memory loss or find it difficult to concentrate. Doctors call these changes in memory and thought processes mild cognitive impairment.
In this study, researchers want to learn more about these side effects. They will use tests that measure thinking skills (cognitive tests) and brain MRI scans.
The main aim of this study is to learn more about how hormone therapy affects the thinking skills of men with prostate cancer.
Who can enter
The following bullet points list the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you.
Who can take part
You may be able to join this study if you are a man and all of the following apply. You:
- have prostate cancer
- can speak and write in English
- are aged between 50 and 85 years old
Who can’t take part
You cannot join this study if any of these apply.
- have had hormone therapy in the past
- have a
- have prostate cancer that has spread to other parts of the body (metastatic)
- have had treatment for prostate cancer that reached your whole body (systemic treatment) and doctors think this may have affected your thinking skills
- have problems with thinking and memory
- have had a stroke
- have had fits (seizures) in the past
- have dementia or Alzheimer’s disease
- take illegal drugs
The researchers hope that around 153 men with prostate cancer will take part. They need:
- 102 men who are going to have hormone therapy
- 51 men who will not have hormone therapy (control group)
Everyone taking part meets with a member of the study team. They will ask you some questions to test your memory and attention. This is to make sure that you don’t have any problems with your thinking skills. This takes about an hour.
You will not be able to continue in this study if the study team finds that you have any difficulties. They will discuss this with you and let your GP know so they can offer you any support you need.
You continue in this study if the researchers don’t find any problems. You will have a blood test. The study team wants to look for certain proteins (genetic markers) that can tell if someone is at risk of having problems with their thinking.
You then complete some simple paper based tests and questionnaires. For example, the tests will ask you to recall pictures and words, and complete some reading. This takes about 4 and a half hours, but you can have breaks during the test so it’s not too tiring.
You have a brain MRI scan either on the same day or, if you prefer, within 2 weeks. This takes around an hour. The study team will also ask you to give a saliva sample. They want to measure the levels of hormone testosterone in your body.
After 6 months, you complete more paper based tests and questionnaires, and have another brain MRI scan. The study team asks you for another saliva sample.
Another 6 months later, you complete the final set of paper based tests and questionnaires. You also give another saliva sample.
You go to the University of Birmingham or Aston University to see the study team and to have the MRI scans. You have up to 5 visits in total and you will be reimbursed for your time and travel. The visits take place over a 12 month period.
There is more information about this on the CogCan research study website.
The study team might find problems with your memory and attention. Finding out that you have problems with your thinking can be upsetting. But the team will be able to ask your GP to investigate this, so that you can get the support you need.
You can also feel unwell after the blood tests, but this is rare. The study team will tell you about all the possible side effects before you take part in this study.
How to join a clinical trial
Professor Elizabeth Grunfeld
Birkbeck University of London
Kings College London
Prostate Cancer UK