A study looking at an MRI scan to diagnose non small cell lung cancer (Streamline L)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Lung cancer
Non small cell lung cancer





This study is looking to see if a whole body MRI scan may be able to replace a range of tests for diagnosing non small cell lung cancer.

If your doctor thinks you may have a type of lung cancer called non small cell lung cancer, you will have a number of tests to find out. If you have cancer, you will also have tests to work out the size of the cancer, and whether or not it has started to spread away from your lungs. This is called the stage of lung cancer. It is important for doctors to know this so that they can choose the right treatment.

More about this trial

Researchers in this study are looking at a type of scan called whole body MRI (or WB MRI), which may in future help people needing tests for diagnosis. WB MRI can scan your whole body in about an hour. MRI scans have been used for a long time, but using an MRI to look at the whole body is quite new. It may benefit people having cancer tests or who have just been diagnosed, as it may replace a number of the usual tests and hospital visits.

People taking part will have all the tests you would usually have to diagnose and stage non small cell lung cancer. But they will also have a WB MRI scan for the study. The aims of this study are to find out if using WB MRI is better or quicker at working out the stage of newly diagnosed cancer than the tests used at the moment. And, to find out the cost of using WB MRI compared to the tests you would usually have.

Who can enter

You may be able to enter this study if you are either

  • Having tests because your doctor thinks you may have a type of cancer called non small cell lung cancer


  • You have non small cell lung cancer that is only in one lung, hasn’t spread to another part of your body and has not caused a collection of fluid around your lung or heart (stage 3b or less), and doctors think you can have treatment aimed to cure your cancer

You must also be

You cannot enter this study if you

  • Would not be able to have an MRI scan for any reason, such as you have some metal or a pacemaker Open a glossary item in your body, you cannot lie flat or you feel very uncomfortable in small spaces
  • Are pregnant

Trial design

This study will recruit 353 people. Everyone taking part will have a WB MRI scan.

The scan will take about an hour. You lie on your back in the scanner. The staff will then give you an injection of MRI contrast through a needle into a vein. This helps the MRI pictures show up more clearly.

You will need to hold your breath from time to time during the scan. The radiographers will tell you when to do this. You will be able to press an emergency button if you need to for any reason.

You will keep a diary each week to record

  • The medication you are taking
  • How many times you visited hospital or your GP, and what this was for

The team will use this to work out how much your medical care costs. You also fill out a short questionnaire about your health and how you have been feeling. This is called a quality of life study. You fill this out at the start of the study and regularly during it. You send the diary and the questionnaire in to the team every 3 months in a prepaid envelope.

The team will collect medical information about you over the next year. This includes the treatment you have and the results of any surgery or tissue samples (biopsies).

The team would also like to find out what people feel about the whole investigation process for non small cell lung cancer. They will ask 50 people to complete questionnaires. If you fill out the questionnaires, you do this every 3 months for a year.

You do not have to join this part of the study if you don’t want to.

Hospital visits

The WB MRI scan will take about an hour, and may be at a different hospital to the one you usually go to. The team will pay your travel expenses for the WB MRI scan.

If you complete the questionnaires, the team will pay you a small fee for your time – they will tell you more about this.

Side effects

Side effects from the MRI contrast injection (gadolinium) include feeling sick, and a skin rash, which is temporary.

It is possible the WB MRI may pick up on new medical problems you didn’t know about. If this happens the team will tell your doctor so they can decide what to do.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Stuart Taylor

Supported by

Cancer Research UK & UCL Cancer Trials Centre
NIHR Clinical Research Network: Cancer
NIHR Health Technology Assessment (HTA) programme
University College London (UCL)

If you have questions about the trial please contact our cancer information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Charlie took part in a trial to try new treatments

A picture of Charlie

“I think it’s really important that people keep signing up to these type of trials to push research forward.”

Last reviewed:

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