A study looking at laser light as a possible new way to diagnose bowel cancer

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Bowel (colorectal) cancer
Colon cancer





This study is using laser light to study samples of bowel tissue. Doctors usually test for bowel cancer by removing samples of bowel tissue (biopsies), and sending them to a pathologist Open a glossary item to study under a microscope. Researchers are looking at a possible new way of testing for bowel cancer, using laser light, called Raman spectroscopy.

More about this trial

With Raman spectroscopy, the doctor shines a laser onto the bowel wall and a computer reads how the light is scattered back off the tissue. Normal and abnormal cells will cause the light to scatter in different ways. The computer tells the doctor how likely the tissue is to be normal, pre cancerous or cancerous.

But before this can be used on people, it needs to be tested on samples of tissue. People taking part in this study will give extra samples of bowel tissue during a colonoscopy or bowel surgery they are already due to have. The research team will use these samples to further study Raman spectroscopy. And to see how this may be developed into a test for bowel cancer in the future. This work is at a very early stage, but they hope that if successful, in future it may help doctors diagnose bowel cancer earlier, without long and possibly uncomfortable procedures.

You will not have any direct benefit from taking part in this study, and it is unlikely to change your treatment plan in any way. But the results of the study will be used to help people in the future.

Who can enter

If you are suitable to join this study, your hospital doctor will ask if you would like to take part. People taking part will

  • Be under the care of the Gloucestershire Royal Hospital
  • Be due to have a routine colonoscopy, or surgery to remove part of their bowel (colorectal resection)

You cannot enter this study if you are known to have Hepatitis B, Hepatitis C, HIV or MRSA.

Trial design

This study will recruit 500 people. Everyone will give permission for the study team to collect a small number of extra tissue samples during their planned colonoscopy or surgery, which is not part of the study. You will also give permission for the team to collect information from your medical notes.

All information the team collect about you will be kept confidentially.

Hospital visits

As the team are collecting samples during a procedure you were already due to have, you will not have to make any extra hospital visits to take part in this study.

Side effects

The team do not expect you to have any side effects as a result of taking part in this study. You can find out more about colonoscopy.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Catherine Kendall

Supported by

Biophotonics Research Group
Bowel Disease Research Fund
Cancer Research UK
Department of Health and Department of Trade and Industry (Health Technology Development Scheme)
Engineering and Physical Sciences Research Council (EPSRC)
NHS Research and Development
NIHR Clinical Research Network: Cancer

If you have questions about the trial please contact our cancer information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Around 1 in 5 people take part in clinical trials

3 phases of trials

Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.

Last reviewed:

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