A study looking for a way to identify breast cancer and to check how well treatment is working (EBLIS)

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Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Breast cancer





This study is looking for substances in blood and tissue samples to help identify breast cancer sooner and to check how well it is responding to treatment.

More about this trial

Doctors use changes in substances in the blood and tissue (biomarkers Open a glossary item) to diagnose breast cancer.

The researchers want to see if they can identify a pattern of change in these biomarkers. They hope to use this information to develop a blood test doctors can use to identify breast cancer and to check how well the cancer is responding to treatment.

Taking part in the study will not affect your treatment and may not help you directly. The information from this study may in the future help doctors to diagnose people with breast cancer sooner and to find out how well treatment is working.

Who can enter

You may be able to join this study if you are a woman and all of the following apply. You

  • Have breast cancer
  • Have had surgery and finished all chemotherapy treatment within the past 3 years
  • Have a high risk of your cancer coming back (relapse) or of dying from your cancer at 10 years if you don’t have any treatment. This might be based on specialised computer programmes (either Adjuvant! Online or NHS Predict). Your doctor can discuss this with you further. 
  • Are at least 18 years old

You cannot join this study if any of these apply. You

  • Have breast cancer that has spread to another part of your body
  • Have had any other type of cancer
  • Have any other medical condition or mental health problem that the researchers think could affect you taking part in this study

You cannot join this study if you had cancer drugs to shrink your cancer before having surgery (neo adjuvant therapy) and your original cancer was less than 2cm across. 

Trial design

The researchers need 194 people to join this study.

The researchers will take a blood sample from you each time you have a hospital appointment.

They will also ask for a sample of your cancer that was removed when you had surgery or a biopsy Open a glossary item. They will also ask for another sample if you need to have further biopsies while you are taking part in the study.

Hospital visits

You see the doctor for a physical examination and blood sample when you agree to take part. You then see the doctor every 6 months for 4 years for an examination and blood tests.

Side effects

You may feel some discomfort or have some bruising where the blood sample is taken.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Charles Coombes

Supported by

Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
Imperial College Healthcare NHS Trust

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Harriet wanted to try new treatments

A picture of Harriet

“I was keen to go on a clinical trial. I wanted to try new cancer treatments and hopefully help future generations.”

Last reviewed:

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