A study looking at how chemotherapy can affect the memory of young adults

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Blood cancers
Breast cancer
Ovarian cancer
Testicular cancer





This study is trying to find out if having chemotherapy can affect the memory of young adults.

Doctors often use chemotherapy to treat cancer.  Some studies have suggested that chemotherapy drugs can affect a person’s memory and how they understand and deal with information.  This is called chemo brain.  But these studies did not include young adults.  And it is not clear which chemotherapy drugs might do this.  The researchers want to do some tests to find this out.

They want to compare the results of the tests of young adults who are having chemotherapy with those of young adults who aren't having chemotherapy.

Who can enter

You may be able to enter this trial if

  • You have just been diagnosed with lymphoma, sarcoma, germ cell cancer or breast cancer or have been diagnosed with one of these cancers and you have been in remission Open a glossary item for between 6 months and 5 years
  • Your treatment includes (or included) the chemotherapy drug doxorubicin
  • You are 16 to 50 years old

You cannot enter this trial if you

  • Have already had chemotherapy
  • Are having radiotherapy
  • Are having hormone therapy – you may be able to take part if you are using the contraceptive pill or if you have had it throughout your breast cancer treatment
  • Have had an injury to the brain
  • Have a mental health problem
  • Are known to misuse alcohol or drugs
  • Are taking medications that could affect your concentration or mood, for example anti depressants – your doctor can advise about this

Trial design

This study will recruit 100 people.

Everyone will do a few tests to check your concentration and how you understand and deal with information.  You do these tests only once.

You also do a short memory test, 1 a day for 3 days in a row.  A member of the study team will show you some words on a computer screen.  You then tell the researcher what you saw, straight away and again on the next day.  This will take about 10 minutes on each occasion.

The researchers will also ask you to take other psychological tests.  These will look at how anxious you are, how you are feeling and how tired you are.  You do the first when you agree to take part in the study.

The study team will ask if you have a friend, relative or colleague about the same age who is not having chemotherapy and might agree to take part in the study.  With your permission they will ask them if they would like to take part.

Hospital visits

The study team will try to arrange to see you when you come to hospital to see your doctor or when you are having medical tests done.

Side effects

There are no side effects if you decide to take part in this study.

We have more information about the side effects of chemotherapy and doxorubicin.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Oana Lindner

Supported by

Medical Research Council (MRC)
National Institute for Health Research Cancer Research Network (NCRN)
University of Manchester

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 8913

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Wendy took part in a new trial studying the possible side effect of hearing loss

A picture of Wendy

"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”

Last reviewed:

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