"I am glad that taking part in a trial might help others on their own cancer journey.”
A study looking at the genetics of chronic lymphocytic leukaemia
Cancer type:
Blood cancers
Chronic leukaemia
Chronic lymphocytic leukaemia (CLL)
Leukaemia
Status:
Results
Phase:
Other
This study tried to find out more about the genes that might cause chronic lymphocytic leukaemia.
More about this trial
In this study the researchers looked at the family history and genes of a large number of people with chronic lymphocytic leukaemia (CLL) and compared them with people who do not have CLL.
The aim of this study was to identify genes that might increase the risk of CLL.
Summary of results
The study team identified 10 changes in genes that might increase the risk of chronic lymphocytic leukaemia (CLL).
About this study
This study was part of a meta analysis 
to identify new gene changes that might increase the risk of CLL. There were 4 studies in the meta analysis. The total number of people in the studies were:
to identify new gene changes that might increase the risk of CLL. There were 4 studies in the meta analysis. The total number of people in the studies were: - 3,100 people who had CLL
- 7,667 who didn’t have CLL
The gene changes researchers looked for are called single nucleotide polymorphisms (SNPs).
(SNPs).After identifying promising SNPs, the team repeated the process to check that the results could be used for everyone and were reliable. This is called a replication study. In this study there were:
- 1,958 people who had CLL
- 5,530 people who didn’t have CLL
Results
Previously 13 SNPs have been identified as being linked to the risk of CLL.
In this study the team have identified a further 10 SNPs that might increase the risk of CLL.
The place where 5 of these SNPs are located on the DNA suggest that they could be involved with the programmed death (apoptosis ) of CLL cells.
) of CLL cells. Conclusion
This study adds support to the importance of gene changes have in the development of CLL. Further studies are needed to find out:
- how this might be able to suggest new ways to prevent and treat CLL
- the importance of the 5 SNPs that might be involved in CLL cell death
Where this information comes from
We have based this summary on information from the research team. The information they sent us has been reviewed by independent specialists (peer reviewed ) and published in a medical journal. The figures we quote above were provided by the trial team who did the research. We have not analysed the data ourselves
) and published in a medical journal. The figures we quote above were provided by the trial team who did the research. We have not analysed the data ourselvesRecruitment start:
Recruitment end:
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.
Chief Investigator
Professor Angela Cox
Supported by
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
National Cancer Institute (NCI)
University of Sheffield
University of Utah
Freephone 0808 800 4040
Last review date
CRUK internal database number:
7094
Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.
Cara took part in a clinical trial
