A study looking for biomarkers of ovarian cancer

Cancer type:

Ovarian cancer





In this study researchers are looking at the blood and tissue samples of women who are having their ovaries removed by surgery. It is open to women who have ovarian cancer and non cancerous (benign Open a glossary item) conditions.

More about this trial

Researchers will look for substances (biomarkers Open a glossary item) in these samples. They will compare the level of the substances in the samples of both groups of women. 

The main aim is to identify biomarkers that might help doctors diagnose ovarian cancer earlier.

Who can enter

The following bullet points list the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you. 

You may be able to join this study if you are at least 18 years old and are in one of the following situations. You

  • are having surgery to remove your ovaries 
  • are having a sample of tissue (biopsy Open a glossary item) taken from your ovaries or omentum Open a glossary item because you might have cancer 
  • have Lynch syndrome Open a glossary item and are having both your ovaries removed to reduce the risk of having cancer
  • are having your womb removed (hysterectomy) Open a glossary item or your ovaries removed (oophorectomy) Open a glossary item because you have a non cancerous (benign) condition such as menorrhagia or fibroids and you have had an ultrasound scan Open a glossary item that shows your ovaries are normal

You cannot join this study if any of these apply. You

  • have an infection 
  • are unable to understand English well enough or English isn’t your first language 

Trial design

The researchers need 224 people with ovarian cancer and 224 people who have a benign (non cancerous) condition to join. 

The researcher will 

  • ask you a few questions about your health 
  • take a blood sample
  • ask for a sample of your ovary tissue removed when you have surgery

The team use the samples to look for substances (biomarkers). These biomarkers might help doctors diagnose ovarian cancer earlier. And also tell them if treatment is working.

Hospital visits

There are no extra hospital visits.

Side effects

We have information about surgery to remove ovarian cancer



Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Lavinia Margarit

Supported by

Abertawe Bro Morgannwg University Health Board
Cwm Taf Morgannwg University Health Board
NIHR Clinical Research Network: Cancer
St David's Medical Foundation
Welsh Government 

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Charlie took part in a trial to try new treatments

A picture of Charlie

“I think it’s really important that people keep signing up to these type of trials to push research forward.”

Last reviewed:

Rate this page:

No votes yet
Thank you!
We've recently made some changes to the site, tell us what you think