A study looking at the effect of helpful chemicals in fruit and vegetables on bowel health in people with a pre cancer or cancer of the bowel

Cancer type:

Bowel (colorectal) cancer





This study looked at how the bowel breaks down chemical compounds called polyphenols, and at how they affect bowel health.

Diets full of fruit and vegetables are linked with a decreased risk of developing age related diseases including cancers of the stomach, bowel and back passage (rectum).

Bowel cancer is strongly linked to diet. Most people diagnosed with bowel cancer are over 50 years old. Doctors want to understand how diet affects bowel health, so they can recommend diets that may help prevent these diseases.

More about this trial

We know that some compounds in colourful fruit and vegetables such as tomatoes, onions and berries gather and build up in the large bowel. These compounds are called polyphenols. They are broken down by bacteria Open a glossary item in the gut into smaller compounds that may protect the gut.

There has only been a small amount of research into how polyphenols in the diet affect bowel health in older adults.

The aim of this study was to compare how gut bacteria break down these compounds in adults over 50 who either have a pre cancerous bowel growth called an adenoma, or bowel cancer, with those who have not.

Summary of results

We have contacted the study team who tell us they don’t expect to be making results available for this study. 

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Campbell Roxburgh

Supported by

NHS Greater Glasgow and Clyde
NIHR Clinical Research Network: Cancer
Saudi Arabian Ministry of Higher Education
University of Glasgow

If you have questions about the trial please contact our cancer information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Last reviewed:

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