A study looking at a drug called BMN 673 in people with a solid tumour that has spread, or has come back after treatment

This study is learning more about a new drug called BMN 673, which hasn’t been tested in people before. It is for people who have a solid tumour that has spread or come back after treatment. A solid tumour is any type of cancer, except for leukaemia or lymphoma.

When cells divide, mistakes sometimes happen in their DNA. DNA is the genetic code that tells cells how to behave. If the mistakes are not repaired, the cell will usually die. If these cells survive, and collect enough of these genetic mistakes, they may eventually become cancer cells.

Some cancer cells rely on a protein called PARP to repair their DNA and help them survive. This study is looking at a new drug called BMN 673 that can stop PARP from working, so these cancer cells should die. But so far it has only been tested in the laboratory. This study is the first time it will be tested in people, so the research team do not know how BMN 673 may affect them. The main aims of this study are to

• Find the highest, safe dose of BMN 673 that you can have daily

• Measure the levels of BMN 673 in your bloodstream

• See if BMN 673 causes any change to your cancer

You will not get any direct benefit from taking part in this study, but the results will be used to help people with cancer in the future.