A study looking at a drug called alisertib in people with peripheral T cell lymphoma that has come back or continued to grow after treatment (LUMIERE)

You may be able to enter this study if

• You have a type of lymphoma called peripheral T cell lymphoma
• Your lymphoma can be measured by a physical examination and scans
• You have had at least one type of standard chemotherapy for your lymphoma but it has come back after treatment, or got worse
• You have a sample of your cancer stored by the hospital when you were diagnosed, or you would be willing to give a sample (a biopsy) of your lymphoma for the study
• You are willing to use 2 reliable forms of contraception from the start of the study until 30 days after the last dose of study treatment if you are female and there is any chance you could become pregnant, or for 6 months if you are male and there is any chance your partner could become pregnant
• You have veins that the team would easily be able to take blood from (for people who join the chemotherapy group)
• You have satisfactory blood tests
• Are well enough to be up and about for at least half the day (performance status 0, 1 or 2)
• You are at least 18 years old

You cannot enter this study if you

• Have lymphoma that only affects your skin
• Have lymphoma that affects your brain or spinal cord (your central nervous system)
• Have had chemotherapy, radiotherapy, immunotherapy or any other experimental cancer drug in the last 4 weeks (6 weeks if you had nitrosourea chemotherapy )
• Have had radiotherapy to more than a third of your bone marrow (if you have had radiotherapy to your whole body before a stem cell transplant you may still be able to take part)
• Have had a stem cell transplant using your own blood cells in the last 3 months, or ever had a transplant using other people’s stem cells or body organs
• Have had a drug similar to alisertib before, or have had both pralatrexate and gemcitabine chemotherapy (if you have only had one of these chemotherapy drugs, you may still be able take part)
• Have had injections of growth factors or a transfusion of platelets in the last 2 weeks
• Are taking drugs that would affect the action of proteins in the body called enzymes , including drugs called CYP3A4 inhibitors – you can ask your doctor about this
• Have taken steroids in the last 7 days (if you have been taking a low dose of prednisone for the last month, or you are taking steroids for sickness, skin conditions or asthma, you may still be able to take part)
• Still have treatment side effects from earlier treatment, apart from hair loss (if the team think that your side effect would not make it unsafe for you to take part you still may be able to join)
• Have had any other cancer, apart from carcinoma in situ of the cervix or non melanoma skin cancer that was successfully treated at least 3 years ago
• Are taking warfarin (if you are taking a low dose of warfarin or another blood thinning drug to stop clots in a central line you may still be able to take part)
• Are taking a drug to reduce stomach acid and cannot stop taking it
• Have had a stroke in the last year
• Have a serious heart problem
• Have had major surgery in the last 2 weeks
• Have any condition that could make you very sleepy during the day, such as stopping breathing during sleep (sleep apnoea), or a group of conditions that cause difficulty breathing, called chronic obstructive pulmonary disease (COPD)
• Have an infection needing antibiotics
• Have an active infection of hepatitis B, hepatitis C or HIV
• Are not able to swallow medication for any reason
• Are pregnant or breastfeeding
• Have any other condition that may make you unwell if you took part, or affect the results of the study – you can ask your doctor about this