A study looking at a drug called alisertib in people with peripheral T cell lymphoma that has come back or continued to grow after treatment (LUMIERE)

This study is comparing an experimental drug called alisertib with the chemotherapy drugs pralatrexate or gemcitabine, in people who have a type of cancer called peripheral T cell lymphoma.

Peripheral T cell lymphoma (PTCL) is a type of non Hodgkin lymphoma, where blood cells called T cells become cancerous. If you have PTCL, you may have treatment with chemotherapy. Sometimes though, the lymphoma can continue to grow during treatment, or come back after treatment.

Researchers in this study are looking at an experimental drug for PTCL, called alisertib. Alisertib can block a particular protein (an enzyme), which may slow down cancer growth by killing the cancer cells.

This study will compare alisertib with the chemotherapy drugs gemcitabine or pralatrexate. The main aims of the study are to

• See how well people respond to alisertib compared to other treatment for peripheral T cell lymphoma

• See if alisertib can control your cancer