
Last year in the UK over 60,000 cancer patients enrolled on clinical trials aimed at improving cancer treatments and making them available to all.
This study was for people with a neuroendocrine tumour in their bowel. It was done to see if having circulating tumour cells can affect how well treatment is likely to work.
The study was open for people to join between 2014 and 2016. The team published the results in 2022.
The neuroendocrine system is made of nerve and gland cells. It makes hormones and releases them into the bloodstream.
Neuroendocrine tumours (NETs) are rare tumours that develop in the cells of the neuroendocrine system. You might also hear them called neuroendocrine neoplasms (NENs) or neuroendocrine carcinomas (NECs). They can develop in a number of different organs of the body, including the bowel.
When this study was done, doctors often used a drug called lanreotide to treat NETs. This is a type of treatment called a somatostatin analogue.
It is possible for small parts of the tumour to break away. They can travel in the bloodstream and grow into new tumours in other parts of the body. These cells are called circulating tumour cells, or CTCs.
In this study, researchers looked for CTCs in blood samples before people had treatment. They wanted to find out if having CTCs in the blood affected how well treatment is likely to work.
The main aim of this study was to find out if having CTCs can affect how well treatment works.
Study design
This study was for people with neuroendocrine tumour in their small bowel that was causing diarrhoea. They were due to start treatment with lanreotide.
The research team looked for circulating tumour cells (CTCs) in blood samples. They looked at whose symptoms got better with treatment, and whether they had CTCs or not.
Results
A total of 40 people had blood tests and completed treatment as part of this study.
The results showed that symptoms improved with lanreotide for 35 out of 40 people (87%) in total. This included:
The team also looked at other proteins (). They didn’t find a link between these proteins and whether people had CTCs or not.
Conclusion
The study team concluded that treatment may be more likely to work for people who don’t have circulating tumour cells. But it’s hard to draw any firm conclusions because of the small number of people in the study.
More detailed information
There is more information about this research in the reference below.
Please note, this article is not in plain English. It has been written for health care professionals and researchers.
Circulating tumour cells and tumour biomarkers in functional midgut neuroendocrine tumours
T Meyer and others
Journal of Neuroendocrinology, 2022. Volume 34, Issue 4.
Where this information comes from
We have based this summary on the information in the article above. This has been reviewed by independent specialists () and published in a medical journal. We have not analysed the data ourselves. As far as we are aware, the link we list above is active and the article is free and available to view.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor Tim Meyer
Experimental Cancer Medicine Centre (ECMC)
Ipsen
NIHR Clinical Research Network: Cancer
Freephone 0808 800 4040
Last year in the UK over 60,000 cancer patients enrolled on clinical trials aimed at improving cancer treatments and making them available to all.