
"He went through six operations and was placed on a clinical trial so he could try new treatments.”
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This study is looking at chemicals and proteins called biomarkers in the blood and urine of children being treated with the chemotherapy drugs cisplatin, ifosfamide or a high dose of methotrexate.
This trial is for children and young people up to and including the age of 18. We use the term 'you', but of course if you are a parent, we are referring to your child.
Doctors often use cisplatin, ifosfamide or methotrexate chemotherapy to treat some types of children’s cancer. Doctors know these drugs can cause kidney damage in some people. In this study they want to look at a particular called KIM-1, as well as other biomarkers in the blood and urine to find out more.
The aims of this study are to
You will not have any direct benefit from taking part in this study, and it is unlikely to change your treatment plan in any way. But the results of the study will be used to help people with cancer in the future.
You may be able to enter this trial if you
You cannot enter this trial if you have a urine infection when you start chemotherapy, until it has been treated.
This trial will recruit 60 children and young people from Alder Hey Children’s Hospital.
Everybody taking part will give blood and urine samples while they have treatment and 6 and 12 months after they finish treatment.
There are no extra hospital visits with this study. You give your blood and urine samples during routine appointments at the hospital.
The researchers may ask you to collect urine samples while you are at home. They will discuss this with you.
You should not have any side effects from taking part in this study.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor Munir Pirmohamed
Alder Hey Children’s Hospital NHS Foundation Trust
NIHR Clinical Research Network: Cancer
University of Liverpool
Freephone 0808 800 4040
"He went through six operations and was placed on a clinical trial so he could try new treatments.”