"He went through six operations and was placed on a clinical trial so he could try new treatments.”
A study looking at the blood and urine of children being treated for cancer (NUMeRICC)
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
Cancer type:
Children's cancers
Status:
Closed
Phase:
Pilot
This study is looking at chemicals and proteins called biomarkers in the blood and urine of children being treated with the chemotherapy drugs cisplatin, ifosfamide or a high dose of methotrexate.
This trial is for children and young people up to and including the age of 18. We use the term 'you', but of course if you are a parent, we are referring to your child.
More about this trial
Doctors often use cisplatin, ifosfamide or methotrexate chemotherapy to treat some types of children’s cancer. Doctors know these drugs can cause kidney damage in some people. In this study they want to look at a particular 
called KIM-1, as well as other biomarkers in the blood and urine to find out more.
The aims of this study are to
- Find out if biomarkers in blood and urine can help to predict who will have kidney damage
- See if some people are more likely to have kidney damage than others, and if there are genetic reasons for this
You will not have any direct benefit from taking part in this study, and it is unlikely to change your treatment plan in any way. But the results of the study will be used to help people with cancer in the future.
Who can enter
You may be able to enter this trial if you
- Are being treated at Alder Hey Children’s Hospital
- Have cancer and are to be treated with cisplatin, ifosfamide or methotrexate
You cannot enter this trial if you have a urine infection when you start chemotherapy, until it has been treated.
Trial design
This trial will recruit 60 children and young people from Alder Hey Children’s Hospital.
Everybody taking part will give blood and urine samples while they have treatment and 6 and 12 months after they finish treatment.
Hospital visits
There are no extra hospital visits with this study. You give your blood and urine samples during routine appointments at the hospital.
The researchers may ask you to collect urine samples while you are at home. They will discuss this with you.
Side effects
You should not have any side effects from taking part in this study.
Recruitment start:
Recruitment end:
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.
Chief Investigator
Professor Munir Pirmohamed
Supported by
Alder Hey Children’s Hospital NHS Foundation Trust
NIHR Clinical Research Network: Cancer
University of Liverpool
Freephone 0808 800 4040
Last review date
CRUK internal database number:
9914
Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.
Rhys was only four years old when he was diagnosed with a brain tumour
