Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.
A study looking at blood samples to find out more about how chemotherapy affects cancer of the food pipe and stomach
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This study is looking at the length of a structure called a telomere to see if it changes during a course of chemotherapy.
All body cells contain
This study is looking at structures at the ends of chromosomes called telomeres. Telomeres act as caps to protect the chromosome. We know from research that telomeres can be shorter than usual when someone has cancer. Researchers think that telomere length may also be important as a marker of how cancer cells might respond to chemotherapy. And of how cells age, which might be important in cancer treatment.
In this study, they will measure telomere lengths in blood samples of people before, during and after a course of chemotherapy. They will look at any changes in the telomeres. And try to see if any changes in these and other markers of ageing cells and cell damage help them understand how chemotherapy affects cancer.
You will not have any direct benefit from taking part in this study, and it is unlikely to change your treatment plan in any way. But the results of the study will be used to help people with cancer in the future.
Who can enter
You can enter this study if you
- Have a type of cancer called
adenocarcinomaof the stomach, the food pipe (oesophagus) or the place where the stomach and food pipe join (the gastro oesophageal junction)
- Have cancer that has spread to nearby tissues (
locally advanced), or to another part of the body (metastatic disease)
- Are due to start a chemotherapy course called ECX or ECF or EOX or EOF OR you will be having EOX and panitumumab as part of the REAL-3 study
- Have cancer that doctors can measure easily
You cannot enter this study if you
- Have any condition that would make it difficult or unsafe for you to give blood samples for the study
- Have had radiotherapy or
systemicanti cancer treatment in the last 6 weeks
- Are pregnant or breastfeeding
You give the study blood samples when you are at the hospital for your treatment or follow up appointment. So you will not need to make any extra visits to take part.
You may have a small bruise where you gave your blood sample.
How to join a clinical trial
Professor Jeff Evans
Experimental Cancer Medicine Centre (ECMC)
Greater Glasgow and Clyde Health Board
NIHR Clinical Research Network: Cancer