
Last year in the UK over 60,000 cancer patients enrolled on clinical trials aimed at improving cancer treatments and making them available to all.
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This study is looking at ways of working out who may be at higher risk of getting lung cancer. The study is supported by Cancer Research UK.
We know that smoking plays a big part in causing lung diseases. But it is not fully understood why some people who smoke get lung cancer and others do not.
Differences in our genes may affect how cells in the airways react to substances in cigarette smoke. In this study, researchers will look at cells from the airways of people who are due to have a test called a bronchoscopy to get a better understanding of these differences. This may help to predict who could be at greater risk of lung cancer.
The study team also want to see if blood cells, and cells lining the nose and mouth, react to cigarette smoke in the same way as cells in the airways. If they do, it may be possible to develop new ways of testing to see who is at higher risk of lung cancer.
You will not get any direct benefit from taking part in this study. But the researchers hope the results can be used to help people in the future.
You may be able to join this study if you
You cannot join the study if you
This study will recruit people who are having a bronchoscopy because they have (or may have) non small cell lung cancer. The study team want to recruit 100 people who are diagnosed with lung cancer. They also want to recruit 100 people who have a bronchoscopy because their doctor suspects they may have lung cancer, but tests show they do not.
If you agree to take part in the study, some extra samples will be taken from your lung during the bronchoscopy. The researchers will take an extra blood sample. They will also take 4 samples from just inside your nose, and a sample from each side of your mouth. They use a small plastic instrument called a curette to gently remove some of the cells from the lining of each side of your nose. They use a small brush to gently take some cells from inside your cheeks.
As well as collecting the samples, the study team will ask you some questions about your past medical history, your smoking history and whether you or any close relatives have ever had cancer or lung disease.
All the samples and information the researchers need for this study are taken on the day you have your bronchoscopy, so there are no extra hospital visits.
Taking the extra samples of lung tissue will add 2 to 3 minutes to the length of time your bronchoscopy takes. Taking the samples of cells from inside your nose takes 2 to 3 minutes. Taking the samples from your mouth only takes about a minute. Answering the questions shouldn’t take longer than 20 minutes.
It is unlikely that the extra few minutes added to the time it takes to do your bronchoscopy will cause you any problems. But if the doctor doing the test thinks that taking extra samples would cause you any harm, they will not collect them.
Taking the samples from your nose can be slightly uncomfortable.
Before you have your bronchoscopy, you have a small plastic tube put into a vein to give you a drug to make you sleepy (a ). The study team will try to take the blood sample from this tube. But if they need to take the blood sample separately, you may have some pain or discomfort and a small bruise.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Robert Rintoul
Cancer Research UK Cambridge Institute
NIHR Clinical Research Network: Cancer
Papworth Hospital NHS Foundation Trust
Freephone 0808 800 4040
Last year in the UK over 60,000 cancer patients enrolled on clinical trials aimed at improving cancer treatments and making them available to all.