A study looking at using urine to screen for cervical cancer (ACES)
Cancer type:
Status:
Phase:
This study is looking at whether doctors can use a urine test as an accurate alternative to the current cervical screening test (smear test).
It is open to people who are having routine cervical screening.
More about this trial
Researchers have developed a urine test that detects the human papilloma virus (
). This is the virus that can cause cervical cancer. Many people have had HPV and their body deals with it. But for some people HPV might cause abnormal cells that could become cancer.
At the moment the only way to test for HPV is by doing a . This is done as part of the NHS cervical screening. However there are a number of reasons why some people are reluctant not to have the test. These include:
- fear of having the screening test
- finding the test uncomfortable
- embarrassment
- difficulty arranging an appointment
Researchers think that a urine test could overcome these barriers and so more people would have cervical screening.
In this study when you go for your routine cervical screening you would be asked to give a sample of urine before the test.
The aims of this study are to find out:
- whether the urine test can detect HPV
- whether the test can be used to screen for cervical pre cancer
- how acceptable the urine test is
Please note you won’t get any direct benefit from taking part. The information gained from this study might help how people have cervical screening in the future.
Who can enter
The following bullet points are a summary of the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you.
Who can take part
You may be able to join this study if all of the following apply. You are:
- part of the NHS cervical screening programme or are seeing the doctor because you have an abnormal cervical screening result
- 24 to 70 years old
Who can’t take part
You cannot join this study if any of these apply. You:
- are pregnant
- have had a
hysterectomy - can’t give a urine sample
- have another medical condition or mental health problem that the study team think could affect you taking part
Trial design
The study team need up to 2,000 women who are having cervical screening to take part.
When you go for your next screening appointment:
• a member of the team will ask you about your
• you give a urine sample
You do the urine sample before seeing the GP for your smear test. A member of the staff tells you how to take the sample.
You must not pass urine in the hour before giving the urine sample.
Optional questionnaire
You fill in a short questionnaire. It asks:
• what you think about having the cervical test and the urine test
• where you would prefer to do the screening in future for example at the GPs or at home
You don’t have to agree to do this questionnaire.
Hospital visits
There are no hospital visits or extra GP visits if you take part.
Side effects
There are no side effects if you take part.
Location
Recruitment start:
Recruitment end:
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Chief Investigator
Professor Emma Crosbie
Supported by
University of Manchester
National Institute for Health Research (NIHR)
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
