A study looking at using a combination of imaging methods to better assess brain tumours

Cancer type:

Brain (and spinal cord) tumours

Status:

Open

Phase:

Pilot

This study is looking at combining a PET scan with an MRI scan to assess brain tumours. This is for people who are going to have surgery for a type of brain tumour called a glioma.

More about this trial

To assess brain tumours doctors can use scans such as an MRI scan. The MRI scan is good at showing where the tumour is and how big it is. But it can’t show other features of the tumour such as how fast it is growing.

The researchers want to combine the MRI scan with another scan called a PET scan. They think that this combination might be better at showing these other features of the brain tumour. This information would be helpful when planning further tests or treatments.

The main aim of this study is to see if the combination of an MRI scan and PET scan is better at giving more detailed information about a brain tumour than an MRI scan only.

Who can enter

You may be able to join this study if all of the following apply

  • If you have had a scan that shows your tumour is getting worse or your symptoms are getting worse
  • You are willing to use reliable contraception
  • You are between 18 and 80 years old

You cannot join this study if any of these apply. You

  • Have already had treatment for your brain tumour
  • Have another cancer
  • Are not able to have an MRI scan, for example if you have certain types of metal surgical clips or plates in your body or you have a pacemaker
  • Are not able to lie still and flat on your back for up to 70 minutes
  • Are taking certain medications, such as diazepam or temazepam, unless you are able to stop them for a few days (the trial team can advise you about this)
  • Have had an antibiotic Open a glossary item drug called minocycline in the past 3 months
  • Have another medical condition that the trial team think could affect you taking part
  • Are pregnant or breastfeeding

Trial design

This is a pilot study. The researchers need 25 people to join. 

The team will ask for 2 PET scans and an MRI scan before your surgery. One of the PET scans is optional you don't have to have the 2nd PET scan if you don't want. 

These scans will usually be done within 14 days before your surgery.

Before the scans a member of the study team will put a small plastic tube (cannula) into a vein in your arm. They will use this to inject a contrast medium Open a glossary item for the MRI scan and a radioactive liquid Open a glossary item for the PET scan.

The study team will ask for a sample of tissue (biopsy Open a glossary item) from your tumour when you have surgery. They will use this to find out more about brain tumours.

Hospital visits

You have the PET scan and MRI scan on the same day. Each scan takes about 70 minutes. You will usually have a couple of hours break between the scans.

Side effects

Both the MRI scan and PET scan are safe tests.

Location

Cambridge
Leeds
Liverpool
Salford

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Alan Jackson

Supported by

NIHR Clinical Research Network: Cancer
University of Manchester

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

12743

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Rhys was only four years old when he was diagnosed with a brain tumour

A picture of Rhys

"He went through six operations and was placed on a clinical trial so he could try new treatments.”

Last reviewed:

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