"He went through six operations and was placed on a clinical trial so he could try new treatments.”
A study looking at the way carboplatin, cyclophosphamide and etoposide chemotherapy works in children under two with cancer (PK 2006 09)
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Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
The aim of the study is to find out more about how carboplatin, cyclophosphamide and etoposide chemotherapy work in children under 2 years of age with any type of cancer.
Carboplatin, cyclophosphamide and etoposide are chemotherapy drugs used to treat adult and childhood cancers. But there is very little information about what happens to these drugs when they enter the bloodstream of very young children.
Researchers want to find out more about how very young children get rid of these chemotherapy drugs and what affects the levels in the blood. Younger children’s liver and kidneys are still developing and this can affect how their bodies get rid of the chemotherapy drugs.
The researchers will collect blood samples from children under 2 and measure the amount of carboplatin, cyclophosphamide or etoposide in their blood at different times. The medical name for this kind of study is
The results of this study may help doctors to improve the way they give treatment for children under the age of 2.
Who can enter
Your child can enter this trial if he or she
- Has any cancer
- Is under the age of 2
- Is having carboplatin, cyclophosphamide or etoposide chemotherapy as part of their treatment for cancer
- Has a central line or long line
Your child cannot enter this trial if he or she
- Is having treatment for a fungal infection with certain types of drugs such as voriconazole or fluconazole
- Is having treatment with drugs to control fits (seizures)
- Is having long term steroid treatment
The trial team will take several blood samples before and during one cycle of chemotherapy.
The researchers will measure the levels of chemotherapy in each blood sample. They will also look for any genetic factors that may affect the level of chemotherapy in your child’s blood.
In all, the trial team will take a total of 3 teaspoons of blood from your child’s central line. These samples are on top of any blood tests that they might have as part of their treatment.
Your child will not have any extra hospital visits as a result of taking part in this trial.
Every time your child’s line is used to take blood or give drugs, there is a very small risk of getting an infection in the line. This risk is very small as nurses will take the blood samples very carefully in a sterile (germ free) way.
How to join a clinical trial
Dr G. Veal
Professor A. Boddy
Cancer Research UK
Children's Cancer and Leukaemia Group (CCLG)
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
Northern Institute for Cancer Research
The Newcastle upon Tyne Hospitals NHS Foundation Trust
University of Newcastle