A study looking at the MCM5 test to diagnose gynaecological cancers

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Ovarian cancer
Womb (uterine or endometrial) cancer

Status:

Closed

Phase:

Other

This study is to see if testing for the MCM5 protein could help diagnose ovarian cancer and womb (endometrial) cancer.

More about this trial

The symptoms of ovarian cancer can be vague. This means this cancer is often diagnosed at an advanced Open a glossary item stage. 

Being diagnosed at an advanced stage can reduce the length of time women live after their treatment. So a test to diagnose ovarian cancer early could help these women live longer. 

Most women with womb cancer are diagnosed at an early stage. But some are diagnosed at a more advanced stage. As with ovarian cancer this can make successful treatment more difficult.  

The aim of this study is to find out if the MCM5 test can diagnose ovarian and womb cancer at an early stage.

Who can enter

The following bullet points list the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you. 

You may be able to join this study if all of the following apply. You

  • Are going to the gynaecological cancer clinic at St Mary’s Hospital, Central Manchester University Hospitals NHS Foundation Trust 
  • Have ovarian cancer or womb cancer or your doctor thinks you might have ovarian cancer or womb cancer 
  • Are at least 18 years old

You cannot join this study if any of these apply. You

  • Have never had sexual intercourse
  • Have already had chemotherapy or radiotherapy for your cancer 
  • Have previously been diagnosed with bladder cancer or kidney (renal) cancer 
  • Have had a test where a tube is inserted into the bladder or the tubes that carry urine from the bladder to the outside of the body (urethra) in the 2 weeks before the MCM5 test is taken for this study 

Trial design

This is a feasibility study. The researchers need 60 women to join.

Everyone gives a urine sample. 

You then either have a vaginal swab taken or you will be given a tampon (with an applicator) to use. 

A research nurse takes the vaginal swab in the clinic. 

You take the tampon home. A member of the study team will phone to tell you when to put the tampon in. You leave it in for 6 to 8 hours. 

You give the tampon to the research nurse at your next clinic appointment. 

Hospital visits

There are no extra hospital visits

Side effects

There are no side effects. You might feel a bit of discomfort if you have the vaginal swab done. 

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Richard Edmondson

Supported by

Arquer Diagnostics Ltd

Freephone 0808 800 4040

Last review date

CRUK internal database number:

14611

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Over 60,000 cancer patients enrolled on clinical trials in the UK last year.

Last reviewed:

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