A study looking at the genetics of children’s cancer (StratMedPaediatrics)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

All cancer types
Children's cancers
Secondary cancers





This study is for children and teenagers whose cancer has come back or treatment has stopped working. It is looking for gene changes to try to understand more about children’s cancers.

It is for children and young people who have one of the following:

  • a solid tumour Open a glossary item including a brain tumour
  • cancer of the lymphatic system (lymphoma Open a glossary item)
  • leukeamia Open a glossary item

We use the term ‘you’, but of course if you are a parent, we are referring to your child.

Cancer Research UK supports this study.

More about this trial

Researchers are trying to learn more about the genetic Open a glossary itemchanges in children’s cancers. In this study they plan to look at tissue samples (biopsies Open a glossary item) and blood samples. They are looking at certain changes (mutations Open a glossary item) in the DNA Open a glossary itemof the cancer cells.   

The study team collect information about your cancer type and treatment. They will also look for gene changes. They will see if there are any links between these gene changes and how well your treatment has worked.

Knowing whether you have a genetic change could help doctors to guide treatment. And find out who benefits most from certain treatments such as targeted drugs. These drugs attack specific changes in a cancer. Finding these targets may help to select who will or won’t benefit from treatment.

In this study researchers aim to:

  • learn more about the genetic changes in your tumour 
  • learn more about the genetic changes of cancers that have come back in children and young adults
  • understand more about how genetic changes cause cancer in children and young adults
  • find out how many people tested are suitable for possible targeted therapies
  • use this information to design future clinical trials 

Please note, you might not benefit directly from taking part. Taking part helps to diagnose and treat children and young people with cancer in the future. 

Who can enter

The following bullet points list the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you. 

Who can take part

You may be able to join this study if all of the following apply. 

  • You are a child or teenager or your cancer was diagnosed in childhood.
  • You have any solid tumour,  lymphoma or leukaemia 
  • You have cancer that has come back or treatment has stopped working.
  • There is a sample of tissue Open a glossary item (biopsy) available from a routine biopsy or surgery that was done within 8 weeks prior to joining this study. This applies only to those who have a solid tumour.
  • There is a bone marrow sample available that was done within 8 weeks prior to joining the study. This applies only to those who have leukaemia. 
  • The study team ask you to join.

Trial design

The research team tell you about the study and ask if you would like to join it. 

You give a blood sample. Where possible you give this at the same time as your routine blood samples. 

The research team analyse the blood samples in the laboratory and look for:

  • genetic faults that may increase the risk of cancer
  • cells that have broken away from the tumour and are in the bloodstream. These are called circulating tumour cells (CTCs).

They also ask for a tissue sample from:

  • recent surgery or a biopsy
  • when you were first diagnosed if there is one available 

The researchers use these samples to look for genetic changes in your cancer. They compare the original sample with the most recent sample to see if the tumour changes over time. 

They also ask to store any leftover samples for future research. 

Taking part in this study may or may not change your treatment. The researchers have regular meetings with specialist doctors and scientists. They look at all the results and discuss these using the most up to date information. They make recommendations and talk to your treating doctor. You and your health team decide if any treatment options, including clinical trials, are suitable.

Hospital visits

There aren’t any extra hospital visits as a result of taking part in the study.

Side effects

There are no treatments in this study. You may get a small bruise where you give your blood sample. But apart from that there aren’t any side effects.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Louis Chesler

Supported by

Cancer Research UK
The Institute of Cancer Research
University of Birmingham
Great Ormond Street Hospital for Children NHS Foundation Trust
Royal Marsden NHS Foundation Trust

If you have questions about the trial please contact our cancer information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Last reviewed:

Rate this page:

Currently rated: 2 out of 5 based on 1 vote
Thank you!
We've recently made some changes to the site, tell us what you think