A study looking at high blood pressure and pazopanib treatment (HYPAZ)

You may be able to enter this trial if you

• Have cancer that your doctor plans to treat with pazopanib
• Have cancer that can be measured on CT scan or by blood test for example CA125 or PSA
• Have satisfactory blood test results
• Are well enough to carry out all your normal activities, apart from heavy physical work (performance status 0 or 1)
• Are willing to use reliable contraception if there is any chance that you or your partner could become pregnant
• Are at least 18 years old

You cannot enter this trial if you

• Have high blood pressure
• Are taking medication for high blood pressure
• Have or have had problems with your heart – your doctor will discuss this with you
• Have an abnormal heart trace (ECG )
• Are taking blood thinning tablets called warfarin
• Have problems with bleeding
• Have had a blood clot in your leg (DVT) or lung in the last 6 months
• Have coughed up blood in the last 8 weeks
• Have cancer in your brain or spinal cord (CNS ) unless it has been treated successfully in the last 6 months and no longer causing you any problems
• Have an infection that cannot be controlled with tablets
• Have had major surgery in the last month, or have a wound that hasn’t healed
• Are unable to absorb medication
• Are allergic to pazopanib
• Have had radiotherapy in the last 2 weeks, unless it is to a single area of your body to control pain
• Have had other treatments such as immunotherapy , biological therapy or another experimental drug in the last 2 weeks (or earlier if there is any chance some of the drug could still be in your body)
• Have had pazopanib (or a similar drug such bevacizumab) in the last 12 weeks
• Are still having side effects from earlier treatment, unless they are very mild
• Are pregnant or breastfeeding