"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”
A study looking at 2 new treatments for prostate cancer that does not respond to hormone therapy
Cancer type:
Prostate cancer
Status:
Results
Phase:
Phase 2
This study wanted to see if 2 drugs for diabetes and high cholesterol helped to reduce PSA levels in prostate cancer when hormone therapy was no longer working.
More about this trial
Doctors often use hormone therapy to treat prostate cancer. This treatment usually works well for a few years. But the cancers often become resistant to hormone therapy at some stage.
When this happens you may not have symptoms. But your 
will increase. This shows that your prostate cancer is becoming more active. Doctors may then use other treatments including steroids or chemotherapy. But these treatments often have unpleasant side effects.
Researchers wanted to see if 2 drugs designed to treat other conditions, would help to stabilise or lower the PSA.
These drugs do not have such severe side effects as steroids or chemotherapy. Pioglitazone treats diabetes, but is still safe if you are not diabetic. Fenofibrate treats high cholesterol.
The aims of this study were to:
- see how these drugs affect PSA levels in men with symptom free hormone resistant prostate cancer
- find out more about the side effects
- see how these drugs affected
quality of life
Summary of results
The study team have told us that this trial closed early because they found it difficult to get enough men to take part. This means that they have not been able to do a full analysis of the results.
Recruitment start:
Recruitment end:
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.
Chief Investigator
Dr Jonathan Shamash
Supported by
Barts Health NHS Trust
Experimental Cancer Medicine Centre (ECMC)
Orchid Cancer Appeal
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
Last review date
CRUK internal database number:
2614
Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.
Keith took part in a trial looking into hormone therapy
