A study to help improve how doctors look for and monitor breast cancer (BSMS)
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
Cancer type:
Status:
Phase:
This study is looking at samples from women who have been called back after a screening mammogram, to see if information from substances in their blood could be used to help screen for and monitor breast cancer. This study is supported by Cancer Research UK.
More about this trial
We know that the earlier a cancer is found, the better the chance of successful treatment. Researchers in this study would like to develop a simple test to help doctors more easily spot an early breast cancer, or breast cancer that is coming back after treatment, to get the best possible outcome.
They will look at blood and tissue samples from women who have been asked to come back after a screening mammogram for further tests. They want to know if substances (biomarkers) in the bloodstream called nucleic acids can help with breast screening. They will compare these in all women who are called back.
They will see if there is a link between these biomarkers, mammogram results and findings from the tissue sample (biopsy) taken as part of routine tests. They want to see if these markers could help make the breast screening process more sensitive, specific and accurate.
The aim of this study is to see if biomarkers in the blood can
- Help doctors find breast cancer earlier
- Improve screening methods and how breast cancer is managed
- Help with following up those with breast cancer in the clinic
You will not have any direct benefit from taking part in this study. But the results will be used to help women with breast cancer in the future.
Who can enter
If you are suitable to join this study, a member of the study team will ask if you would like to take part. Women taking part will
- Have had a breast screening mammogram
- Have been asked to come back for further tests at an assessment clinic at Charing Cross Hospital in London
- Be at least 18 years old
You cannot enter this study if you
- Have had any other cancer before, including another breast cancer
- Have had a blood transfusion in the past
- Have any condition that would make it difficult for you to understand the study, or may affect the results of the study - you can ask your doctor about this
The study team will also recruit female volunteers who have not been called back after breast screening, to compare their results with.
Trial design
This study will recruit 2,500 women.
Everyone will give 2 samples of blood for the study:
- when you agree to take part
- another between 3 months and 18 months later
The team will also ask permission for any breast tissue that you have removed.
If you are found to have breast cancer, the team will ask if you would be willing to give further blood samples when you come to hospital for routine blood tests.
Hospital visits
You give your study blood samples when you come to hospital for a routine appointment.
Side effects
You may have a small bruise where you gave your blood sample.
Recruitment start:
Recruitment end:
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Chief Investigator
Professor Charles Coombes
Supported by
Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
Imperial College London
NIHR Clinical Research Network: Cancer
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
