A study to find out what men think is important when making decisions about treatment for prostate cancer (COMPARe study)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Prostate cancer





This is a study to learn more about how men make decisions about prostate cancer treatment.

Prostate cancer that has not grown outside the prostate gland is called localised prostate cancer. If you are diagnosed with localised prostate cancer, you may have different treatment options, including surgery, radiotherapy, cryotherapy, or high intensity focused therapy (HIFU). Or you may not start treatment but be closely monitored instead. This is often called active surveillance.

All the treatments are different. The side effects, and how long these are likely to last are also different. So deciding which treatment to have can be difficult. Researchers want to learn more about how men with prostate cancer make choices between the treatment options they have.

In this study, they will ask men what is most important to them when deciding between one treatment and another. Taking part in this study will not affect the treatment you have.

Who can enter

You may be invited to join the study if you

You cannot volunteer to join this study and you cannot join if you

Trial design

The study is in 2 parts. In the first part (the pilot stage), the researchers asked men what they thought of a questionnaire. The questionnaire is designed to find out what men look at when choosing between treatments.

After filling in the questionnaire, the men had an interview with a researcher. They were asked what they thought were the most important aspects of each treatment included in the questionnaire. This helped the study team to make sure they were including the right things. They also asked the men if they thought the questionnaire was clear and if they thought other men would be willing to complete it.

The study team used the men’s responses to change the questionnaire where needed. They have now moved into the main part of the study.

If you take part, the researchers will ask you to fill in the questionnaire. It includes a number of scenarios. In each scenario, you will be asked to choose between 2 treatment options.

There are also some general questions about your background, how you are feeling and how difficult you find the questionnaire to fill in. And there are 2 questions about any urinary problems you have and your sexual function.

Hospital visits

Taking part in this study doesn't involve any extra hospital visits. You can fill in the questionnaire in hospital or at home. It takes about 30 to 40 minutes. The researchers will give you a stamped, addressed envelope to return it.

Side effects

There are no side effects from taking part in this study.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Mr Hashim Ahmed
Professor Mark Emberton
Dr Verity Watson

Supported by

Medical Research Council (MRC)
NIHR Clinical Research Network: Cancer
University College London (UCL)

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 7840

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Keith took part in a trial looking into hormone therapy

A picture of Keith

"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”

Last reviewed:

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