"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”
A study to find out what men think is important when making decisions about treatment for prostate cancer (COMPARe study)
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This is a study to learn more about how men make decisions about prostate cancer treatment.
Prostate cancer that has not grown outside the prostate gland is called localised prostate cancer. If you are diagnosed with localised prostate cancer, you may have different treatment options, including surgery, radiotherapy, cryotherapy, or high intensity focused therapy (HIFU). Or you may not start treatment but be closely monitored instead. This is often called active surveillance.
All the treatments are different. The side effects, and how long these are likely to last are also different. So deciding which treatment to have can be difficult. Researchers want to learn more about how men with prostate cancer make choices between the treatment options they have.
In this study, they will ask men what is most important to them when deciding between one treatment and another. Taking part in this study will not affect the treatment you have.
Who can enter
You may be invited to join the study if you
- Have been diagnosed with prostate cancer that has not spread outside your prostate gland (stage T1 to T3A)
- Have a Gleason score of 7 or lower, and a PSA level no higher than 15
You cannot volunteer to join this study and you cannot join if you
The study is in 2 parts. In the first part (the pilot stage), the researchers asked men what they thought of a questionnaire. The questionnaire is designed to find out what men look at when choosing between treatments.
After filling in the questionnaire, the men had an interview with a researcher. They were asked what they thought were the most important aspects of each treatment included in the questionnaire. This helped the study team to make sure they were including the right things. They also asked the men if they thought the questionnaire was clear and if they thought other men would be willing to complete it.
The study team used the men’s responses to change the questionnaire where needed. They have now moved into the main part of the study.
If you take part, the researchers will ask you to fill in the questionnaire. It includes a number of scenarios. In each scenario, you will be asked to choose between 2 treatment options.
There are also some general questions about your background, how you are feeling and how difficult you find the questionnaire to fill in. And there are 2 questions about any urinary problems you have and your sexual function.
Taking part in this study doesn't involve any extra hospital visits. You can fill in the questionnaire in hospital or at home. It takes about 30 to 40 minutes. The researchers will give you a stamped, addressed envelope to return it.
There are no side effects from taking part in this study.
How to join a clinical trial
Mr Hashim Ahmed
Professor Mark Emberton
Dr Verity Watson
Medical Research Council (MRC)
NIHR Clinical Research Network: Cancer
University College London (UCL)