A study to find genes that may increase the risk of bowel tumours - The PRESENT Study

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Bowel (colorectal) cancer

Status:

Closed

Phase:

Other

This study is trying to find genes that may increase your risk of bowel cancer or non cancerous tumours called polyps and adenomas.

We know from research that certain genetic factors you inherit from your parents may affect your risk of getting tumours in your bowel. This includes polyps Open a glossary item and adenomas as well as bowel cancer.

In this study, the researchers will look at the genes of a large number of people who have had a tumour in their bowel. They are looking at a certain type called a ‘serrated’ tumour. This means that there are large folds in the tissue of the tumour when looked at under a microscope.

The study team will contact people who have taken part in the NHS Bowel Screening Programme.

They will find out more about people’s family history to see if any of their relatives have also had tumours in the bowel.

The aim of the study is to identify genes that may cause bowel tumours.

Who can enter

You may be able to enter this trial if you

Have had a colonoscopy as part of the NHS Bowel Cancer Screening Programme
Have a bowel tumour that was on the right hand side of your large bowel and was a serrated type - your doctor can advise about this
Are at least 18 years old

You cannot enter this trial if you have an inherited condition with a gene fault that increases your risk of bowel cancer.

Trial design

The study will recruit about 2,000 people.

The study team will send you a letter containing information about the study, and a reply slip. You return the reply slip if you want more information. They will then send you a

Letter containing more information
Questionnaire about you and your family’s medical history
Consent form for you to sign
Blood sampling kit

The study team are also interested in recruiting people who have not had a bowel polyp. So included with the above, will be a letter for you to pass on to a friend or a relative by marriage, such as your spouse or brother in law, who you might think would be interested in taking part in this study.

You give a small sample of blood at your GP surgery or hospital. They will use the blood sampling kit provided by the researchers and send it back to them, along with the completed questionnaire and signed consent form.

The researchers will look at the DNA in the blood samples to try and find genes that may increase the risk of bowel tumours. By signing the consent form, you also give them permission to look at your medical records.

If you have had surgery to remove a bowel tumour, the researchers may get a sample of the tissue that was removed. They will do further genetic tests on this tissue sample.