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A study to determine whether the number and types of bacteria in the gut affects how well treatment works for bile duct cancer (ABC-12)

Overview

Cancer types:

Bile duct cancer, Biliary tree cancers, Gallbladder cancer

Status:

Open

Phase:

Other

Details

This study is looking at whether the number and types of bacteria that live naturally in our bowel affects how well the treatment for biliary cancer works.

It is for people with bile duct cancer that:

  • cannot be removed by surgery and you haven’t had any treatment for it

  • when you were first diagnosed the cancer had spread to another part of the body

  • has come back at least 6 months after treatment with the aim to cure

It is also open to people with gallbladder cancer that has spread or come back least 6 months after treatment with the aim to cure.

Recruitment start: 9 November 2023

Recruitment end: 31 December 2025

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Dr Mairéad McNamara

Supported by

AstraZeneca

The Christie NHS Foundation Trust

Cardiff University Centre for Trials Research

The University of Manchester

Last reviewed: 01 Sept 2025

CRUK internal database number: 18882

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