Last year in the UK over 60,000 cancer patients enrolled on clinical trials aimed at improving cancer treatments and making them available to all.
A study comparing a urine sample and different ways of collecting and transporting vaginal samples for HPV testing
We know that this is an especially worrying time for people with cancer and their family and friends. We have separate information about coronavirus and cancer. Please read that information alongside this page. We will update that information as guidance changes.
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
More about this trial
Having a cervical screening test is the main way you can be diagnosed with abnormalities in your cervix that, if left untreated, could lead to cancer. The sample taken during your cervical screening might also be tested for
But there are newer ways of taking samples that women might prefer.
In this study researchers want to test different ways of taking a sample of the inside of your vagina using different swabs or brushes that you use yourself. They will also ask for a urine sample.
After you have done your samples the researchers will transport the vaginal samples to the lab in different ways. Some will be in liquid and some will be kept dry.
The researchers want to learn
- the best way of collecting vaginal samples and transporting them
- how the results of different tests on these samples and urine compare
They will also compare their findings with results from any samples you have taken during your colposcopy.
Neither you nor your doctor will be told the results of the swabs and urine sample as they are for research purposes only. Taking part in this study will not change any treatment you might need.
Who can enter
The following bullet points list the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you.
You may be able to join this study if you are attending the Royal London Hospital colposcopy clinic for an examination and all of the following apply. You
- Have had an abnormal cervical screening test result
- Are aged 18 or older
You cannot join this study if any of these apply. You
- Have had your cervix removed
- Have had any treatment for cervical intraepithelial neoplasia (CIN) in the last 3 years
- Are pregnant
Researchers hope that 600 women will take part in this study.
At the colposcopy clinic a member of the research team will explain the study to you and give you an opportunity to ask questions. If you decide to take part you’ll sign a
After you sign the form you:
- give a urine sample using a special device designed just to collect the first bit of urine you pass
- take two vaginal samples using either swabs (like a cotton bud but with a longer handle) or special devices with a brush – the researchers will give you written instructions and diagrams on how to do this
- complete a simple questionnaire on your experience of giving the samples
You then continue with your colposcopy appointment as usual.
About 6 months after your appointment the researchers will look at your medical records so they can collect the results of any tests done during your colposcopy.
There are no extra visits if you take part in this study. It all takes place at your colposcopy appointment.
There are no side effects from taking part in this study.
How to join a clinical trial
Mr Tony Hollingworth
Barts Health NHS Trust
Cancer Research UK
Queen Mary University of London