Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.
A study looking at a new fluorescent substance called EMI-137 to help doctors spot bowel cancer during surgery
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
More about this trial
During surgery, doctors try to remove all of the cancer and a border of healthy tissue around it. But it can be difficult for doctors to clearly see where the cancer is with their naked eye. This may lead to some of the cancer being left behind.
In this study, doctors are using a new fluorescent substance called EMI-137. Doctors think that the EMI-137 can light up bowel cancer when they shine a special light onto the bowel.
The main aim of this study is to find out whether the EMI-137 can light up the bowel cancer and any nearby lymph nodes that might contain cancer cells during surgery. This would help the surgeon make sure that they remove the cancer completely.
Who can enter
- you have cancer of the large bowel (colon)
- your kidneys and liver are working well
- doctors think that you are well enough to have an
- you are at least 18 years old
- you are willing to use reliable contraception for 3 months after surgery if there is any possibility that you or your partner could become pregnant
- have had, or are going to have, chemotherapy before surgery (
- are taking part in another clinical trial that uses a fluorescence substance, or have had a fluorescence substance in the past 3 months
- have had an investigational treatment in the last month
- have bowel problems such as inflammatory bowel disease
- are known to be sensitive to fluorescent substances
- have any serious medical condition or mental health problem that the trial team think could affect you taking part
- are pregnant or breastfeeding
Researchers hope that around 10 people who are going to have surgery for bowel cancer will take part.
Between 2 and 3 hours before surgery, you have the EMI-137 as a drip into a vein. You then have the operation using a keyhole (laparoscopic) technique. This means that your surgeon makes small cuts into your tummy (abdomen). They pass a camera through one cut and put the surgical tools through the other cuts.
During the operation, doctors use the camera to look for bowel cancer. They also shine a special light to find out if it helps to see the cancer more clearly. Doctors then try to remove all the cancer they find.
The trial team might take pictures and make videos during the operation. This is so they learn as much as possible from this study. The videos and photographs are anonymised. So no one will be able to identify you.
You don’t have any extra hospital visits as part of this study. You have your surgery at St James’ University Hospital.
You stay in hospital for about a week after surgery. Before you go home, your nurse gives you information about how to care for the wounds.
About 3 weeks after the operation, you have a follow up appointment. This is the same as the standard treatment. During this appointment, the trial doctor will check how you are and see whether you have had any side effects from the EMI-137.
How to join a clinical trial
Professor David Jayne
The Leeds Teaching Hospitals NHS Trust
University of Leeds