Clinical Research Committee

The Clinical Research Committee oversees funding and endorsement of investigator-led clinical trials, and other research supporting or enabling clinical trials.

The priorities of the CRC are set out in our statement of intent and build on those established in the CRUK Research Strategy.

Research areas

CRC maintains a broad portfolio that maximises patient impact. We support a balance of research across the range of modalities and disease sites, conducted in early, pre-invasive, localised disease and metastatic settings.

Our investment priorities include:

  • Cancers of unmet need (lung, oesophageal, pancreatic and brain cancers)
  • Promising, high impact and innovative trials that would not otherwise progress
  • Scientifically-driven studies that use and analyse biomarkers and imaging, producing valuable biological and clinical information that will optimise treatments
  • Hypothesis-driven, data-rich sample collections that support the validation and qualification of valuable biological information
  • Innovative, cost-effective trial designs that can be supported by strategic long-term investments in trial platforms

Funding schemes

CRC reviews, funds and endorses:

We have recently merged the Early Phase and Feasibility Study Award and the Late Phase Clinical Trial Award schemes to create a single Clinical Trial Award scheme in response to the increasing number of ambitious and adaptive early phase trial applications we are receiving that rival late phase applications in terms of duration and complexity.​

On occasion, the CRC also reviews strategic initiatives in areas of high strategic priority, such as cancers of unmet need. These are typically large scale, ambitious research proposals which bring together the research community around a specific problem and which, if successful, would result in a significant step forward against the CRUK research strategy. If you would like to discuss such a concept, please get in touch using the contact details below.

How proposals are judged

The Committee and its Expert Review Panels meet twice a year and assess all applications on the basis of their scientific quality, taking into consideration comments collected from expert peer reviewers. The Committee strategically assess applications based on their alignment to the Statement of Intent for Clinical Research (PDF), and our Research Strategy.

Read terms of reference for this committee

How grants are monitored

Grants are monitored through the Clinical Research Monitoring Panel (CRMP). The Panel meets twice a year to review annual Scientific Milestone Reports and determine whether to continue support.

Read the terms of reference for the CRMP

​Chair of the Clinical Research Committee

Chair Professor Tim Maughan – University of Oxford

Vice Chairs of the Clinical Research Committee

Professor Caroline Dive – University of Manchester

Dr James Larkin – The Institute of Cancer Research/The Royal Marsden

Members of the Clinical Research Committee

Professor Richard Adams – Cardiff University

Dr Jan Bogaerts – EORTC

Dr James Brenton – University of Cambridge

Professor David Cameron – University of Edinburgh

Professor Nandita deSouza – The Institute of Cancer Research

Professor Janet Dunn – University of Warwick

Professor Paula Ghaneh – University of Liverpool

Professor Richard Gilbertson – University Cambridge

Professor Richard Marais – University of Manchester

Professor Gary Middleton – University of Birmingham

Professor Mark Middleton – University of Oxford

Professor Ruth Plummer – University of Newcastle

Mr John Reeve – Patient Representative

Dr Anna Schuh – University of Oxford

Mr Richard Stephens – Patient Representative

Chair of the Clinical Expert Review Panel

Professor David Cameron – University of Edinburgh

Vice Chair of the Clinical Expert Review Panel

Professor Richard Adams – University of Birmingham

Members of the Clinical Expert Review Panel

Professor Sally Barrington – King's College London

Professor Lucinda Billingham – University of Birmingham

Dr Catherine Brain – University of Manchester

Mr David Chuter – Patient Representative

Dr Helena Earl – University of Cambridge

Professor Jeff Evans – University of Glasgow

Professor Corinne Faivre-Finn – University of Manchester

Dr Eve Gallop-Evans – Cardiff University

Dr Darren Hargrave – Great Ormond Street Hospital & University College London

Mr Chris Hurt – Cardiff University

Dr Lynley Marshall – The Royal Marsden

Dr Murielle Mauer – EORTC

Professor Alex Mirnezami – University of Southampton

Dr Karin Oien – University of Glasgow

Dr Sanjay Popat – The Institute of Cancer Research & The Royal Marsden

Mr Richard Stephens – Patient Representative

Mr Grant Stewart – University of Cambridge

Dr Anna Schuh – University of Oxford

Professor Richard Wilson – Queen's University Belfast

​Chair of the Experimental Medicine Expert Review Panel

Dr James Brenton – University of Cambridge

Vice Chair of the Experimental Medicine Expert Review Panel

Professor Mark Middleton – University of Oxford

Members of the Experimental Medicine Expert Review Panel

Dr Simon Bomken – Newcastle University

Dr Sarah Brown – University of Leeds

Professor Ananya Choudhury – University of Manchester

Dr Simon Crabb – University of Southampton

Dr Emma Dean – University of Manchester

Professor Malcolm Dunlop – University of Edinburgh

Dr Adele Fielding – University College London

Professor Charlie Gourley – University of Edinburgh

Dr Geoff Higgins – University of Oxford

Dr Kathreena Kurian – University of Bristol

Dr Michelle Lockley – Queen Mary University of London

Dr Stefan Michiels – Institut Gustave Roussy

Professor Gary Middleton – University of Birmingham

Dr James O’Connor – University of Manchester

Mr John Reeve – Patient Representative

Ms Louise Stanton – University of Southampton

Professor Anne Thomas – University of Leeds

Professor Gareth Thomas – University of Southampton

Professor Andrew Tutt – King's College London & The Institute of Cancer Research

Chair of the Clinical Research Monitoring Panel

Dr James Larkin – The Institute of Cancer Research/The Royal Marsden

Vice Chair of the Clinical Research Monitoring Panel

Professor Paula Ghaneh – University of Liverpool

Members of the Clinical Research Monitoring Panel

Professor Fiona Blackhall - The University of Manchester

Dr Charlotte Coles - The University of Cambridge

Professor Gordon Cook – University of Leeds

Professor Peter Johnson – University of Southampton

Professor Nick Lemoine - Barts Cancer Institute

Mr Jim Paul – University of Glasgow

Mr John Reeve – Patient Representative

Mr Matthew Sydes – University College London

Contact for this committee

Alice Holt

Alice Holt

​Senior Research Funding Manager

clinicalresearch@cancer.org.uk

Tel: +44 (0) 20 3469 5472

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We support a broad portfolio of clinical and translational research through response mode funding, partnership initiatives and investments in clinical infrastructure.