Statement of Intent for Children’s and Young People’s Cancer Research
Cancer in children and young people is different to cancer in adults – from the types of cancer to the specific challenges facing the research community. Our statement of intent outlines how we intend to support researchers to overcome these challenges and drive progress in children’s and young people’s cancer research.
Why we’re prioritising children’s and young people’s cancer research
Despite improvements in overall survival over the last 40 years, cancer remains the leading cause of death by disease in children and young people (aged 0-24) in the UK. Some of these types of cancers continue to have low survival rates and many children and young people who survive do so with series long-term side effects.
We’re investing in this field to better understand the underpinnings of this disparate group of diseases and develop more effective and less toxic treatments to increase chances of survive and improve quality of life for patients after treatment.
Challenges with research into children’s and young people’s cancers
- Too few researchers
- Too little discovery research
- Not enough industry support
- Poor awareness
- Fragmented expertise
- Lack of research tools
How we’re tackling these challenges
We consulted UK and international researchers in the field, as well as patients and parents who have been affected. Following these consultations, we identified three key priorities areas – people, community and infrastructure. By focusing on these areas, we aim to increase high-quality research across the translational pipeline and in all types of cancer affecting children and young people.
We want to support researchers to overcome the challenges so we can increase the chance of survival for children and young people and improve their quality of life during and after treatment.
Build research capacity in the UK
- We launched the Cancer Research UK-Children with Cancer UK Innovation Awards which is supporting five UK teams of world-leading scientists, with up to £1 million each.
- We launched the international SU2C-CRUK Paediatric Cancer New Discoveries Challenge which is supporting three new research collaborations between UK and US labs. Each collaboration will receive $1 million over two years, with possible extensions of $5 million over 3 – 4 years for the most promising projects.
- We recently funded £20 million for the Cancer Grand Challenge team NexTGen, to develop novel therapies to target unique features in solid tumours in children.
Develop and support a coordinated research community
- We will host community building workshops and events to support conversations and collaboration between lab scientists and clinicians, and between scientists from different research fields.
- We will continue to engage and collaborate with research communities not usually associated with children’s and young people’s cancers, encouraging them to apply their wide knowledge and expertise to this area of cancer research.
Ensure the research community has the tools and infrastructure it needs to progress
- We will build and link together resources, for example research data and tissue samples, and fund the development of vital research tools through our funding award schemes.
- All of our funding schemes are open and available for the children and young people cancer research community to fund the development of vital research tools.
- Our Discovery Programme Awards provide long-term support for broad, multidisciplinary research and our Clinical Trial Awards support clinical trials of cancer treatment with the aim of improving patient outcomes.
Our research strategy
Our research strategy shapes how we'll discover more about the mechanisms of how cancer develops and progresses to unlock new and better ways to prevent, detect and treat it.
We remain committed to prioritising cancers that affect children and young people and in the financial year 2021/22, we spent £13.4m on research specific to cancers that affect 0-24-year-olds, making us the biggest charitable funder of research into children’s and young people’s cancers in the UK.
Latest news and feature stories
Paving the way: How biopsies are offering hope to children with aggressive brain tumours
For decades, clinical trials of DIPG were based on work done using samples from adult brain tumours that looked similar to DIPG down a microscope. None of these studies were able to provide answers and because of the lack of actual DIPG samples, there was a gap in our understanding of the biology of the disease.
Childhood cancer survivors at greater risk of ill health
People who survive cancer in childhood have a higher risk of ill health as they grow older, according to new research published in The Lancet Regional Health – Europe.
Delivering the future of paediatric brain tumour therapy
Dr Lisa Ruff tells us why drug delivery is so important for the treatment of paediatric brain tumours – and why hydrogels could be key to a breakthrough…
Thinking outside the box to tackle an aggressive children’s cancer
How our partnership with Children with Cancer UK is helping to transform our understanding of children’s and young people’s cancers.
Kinder and more effective – why childhood cancers need specific treatments
Dr Sally George tells us about her work on neuroblastoma and why childhood cancers really do need specific research to develop the most effective treatments.
Develop your research career
We're committed to supporting the next generation of cancer researchers and we have opportunities for you wherever you are in your career, whether you're new to the lab, or growing your fully fledged independent research group.
We have a broad range of fellowships, bursaries, job opportunities and studentships to cater for your situation.