SU2C-CRUK Paediatric Cancer New Discoveries Challenge

About this scheme

Key information

Career level
Early career researcher
Mid-career researcher
Established independent researcher
Clinician
Non-clinical researcher
Research area
All research areas
Preliminary submission
Final submission
Committee review
Funding period
2 years for round 1, with option to apply for round 2
Funding amount
Up to $1 million in round 1
SU2C-CRUK Paediatric Cancer New Discoveries Challenge aims to support novel and innovative trans-Atlantic collaborations in childhood cancer research.

These awards will support collaborative, multi-disciplinary, multi-institutional, transatlantic teams, comprising laboratory and clinical researchers and those at different career stages.

Teams must be led by at least one researcher from a US institution and one from a UK institution.

You are strongly encouraged to form a team that includes expertise beyond paediatric oncology (e.g. other areas of oncology, biology, chemistry, engineering, physics, etc.).

Scientific remit

Applications can address one or more of the following concepts, with the goal of progressing the approach to a more advanced pre-clinical or clinical setting in round 2:

  • the basis of tumour initiation and progression
  • novel therapeutic approaches
  • development of novel biomarkers or methodologies to predict disease progression, to enhance efforts in primary and secondary prevention and intervention
  • novel models that would enhance pre-clinical research
  • development of more effective and/or less toxic treatments to improve long-term health and quality of life

We would welcome proposals that advance research in any type of paediatric cancer, including teenagers and young adults, particularly inviting new proposals in paediatric brain tumours.

Funding support of up to US$1 million is provided for:

  • Salaries for researchers, technical staff and project manager (US-based senior investigators may apply for a percentage of their salary and benefits expenses)
  • Running expenses
  • Equipment
  • Travel expenses related to the research project

Applicant teams successful in round 1 will also have the opportunity to apply for a second round of funding to progress their research further. 

How to apply to this scheme

Applications should be submitted to Stand Up 2 Cancer. Written proposals will be shortlisted by the JSAC and shortlisted Teams will be invited for an interview in March 2020.

You are encouraged to contact the SU2C office to discuss your eligibility and suitability of your research proposal.

The Joint Scientific Advisory Committee (JSAC) will consider the following criteria when evaluating the proposals: 

  • Scientific merit of the proposed research project and translational line of sight for the research; 

  • Significance of the proposed research, i.e. potential to address an area of critical patient need in the prevention, detection, or treatment of paediatric brain cancer;  

  • Novelty of the hypothesis or methodology;  

  • Team Leader’s vision, leadership qualities, willingness to collaborate, demonstrated ability to bring together and lead an interdisciplinary team of experts to a successful conclusion, expertise in the field, and commitment to translational cancer research;  

  • Willingness of the Team Leader, Co-leader, and Principals to collaborate, their research credentials, and their unique contributions to the Team research project; 

  • A clear commitment by the Team that all data resulting from their work will be available to the scientific community at large at the earliest opportunity; 

  • Likelihood that the research project will achieve its stated goals given the budget requested, institutional environments, and other resources available;  

  • Whether the studies are designed to capitalize upon the unique populations and environments, specialized expertise, new concepts and perspectives, innovative methodologies, and/or emerging technologies that are available as a result of the multi-institutional collaboration; and 

  • Whether adequate institutional and/or financial support exists to sustain the research project. 

Applications will be assessed by the Joint Scientific Advisory Committee (JSAC).

Cancer Research UK contact details

Statement of Intent for Children’s and Young People’s Cancer Research