Acute myeloid leukaemia (AML) incidence statistics

Cases

New cases of acute myeloid leukaemia, 2014-2016 average, UK

 

Proportion of all cases

Percentage acute myeloid leukaemia is of total cancer cases, 2014-2016 average, UK

 

Age

Peak rate of acute myeloid leukaemia cases, 2014-2016, UK

 

Trend over time

Change in acute myeloid leukaemia incidence rates since the early 1990s, UK

 

Acute myeloid leukaemia is not among the 20 most common cancers in the UK, accounting for less than 1% of all new cancer cases (2016).[1-4]

In females in the UK it is not among the 20 most common cancers (less than 1% of all new female cancer cases). In males in the UK, acute myeloid leukaemia is not among the 20 most common cancers (less than 1% of all new male cancer cases).

43% of acute myeloid leukaemia cases in the UK are in females, and 57% are in males.

Acute myeloid leukaemia incidence rates (European age-standardised (AS) rates Open a glossary item) for persons are significantly lower than the UK average in Scotland and Northern Ireland, and similar to the UK average in all other UK constituent countries.

Acute Myeloid Leukaemia (C92.0, C92.4, C92.5, C92.6, C92.8, C93.0, C94.0, C94.2), Number of New Cases, Crude and European Age-Standardised (AS) Incidence Rates per 100,000 Population, UK, 2016

  England Scotland Wales Northern Ireland UK
Female Cases 1,092 100 65 26 1,283
Crude Rate 3.9 3.6 4.1 2.7 3.9
AS Rate 3.9 3.6 3.9 2.9 3.9
AS Rate - 95% LCL 3.7 2.9 2.9 1.8 3.7
AS Rate - 95% UCL 4.2 4.3 4.8 4.0 4.1
Male Cases 1,451 100 90 32 1,673
Crude Rate 5.3 3.8 5.9 3.5 5.2
AS Rate 6.2 4.4 6.3 4.7 6.0
AS Rate - 95% LCL 5.9 3.6 5.0 3.1 5.7
AS Rate - 95% UCL 6.5 5.3 7.6 6.3 6.3
Persons Cases 2,543 200 155 58 2,956
Crude Rate 4.6 3.7 5.0 3.1 4.5
AS Rate 5.0 3.9 4.9 3.7 4.8
AS Rate - 95% LCL 4.8 3.3 4.2 2.7 4.6
AS Rate - 95% UCL 5.1 4.4 5.7 4.6 5.0

95% LCL and 95% UCL are the 95% lower and upper confidence limits Open a glossary item  around the AS Rate Open a glossary item
 

For acute myeloid leukaemia, there are few established risk factors therefore differences between countries largely reflect differences in diagnosis and data recording.

References

  1. Data were provided by the National Cancer Registration and Analysis Service (part of Public Health England), on request through the Office for Data Release, August 2018. Similar data can be found here: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases
  2. Data were provided by ISD Scotland on request, April 2018. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, February 2019. Similar data can be found here: http://www.wcisu.wales.nhs.uk.
  4. Data were provided by the Northern Ireland Cancer Registry on request, April 2018. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 2016, ICD-10 C92.0, C92.4, C92.5, C92.6, C92.8, C93.0, C94.0, C94.2.

Last reviewed:

Acute myeloid leukaemia incidence is strongly related to age, with the highest incidence rates being in older people. In the UK in 2014-2016, on average each year more than 4 in 10 (42%) new cases were in people aged 75 and over.[1-4]

Age-specific incidence rates rise steadily from around age 50-54, more steeply from around age 60-64 and drop in the oldest age group. The highest rates are in the 85 to 89 age group for females and males.

Incidence rates are significantly lower in females than males in a number of (mainly older) age groups. The gap is widest at age 85 to 89, when the age-specific incidence rate is 1.9 times lower in females than males.

Acute Myeloid Leukaemia (C92.0, C92.4, C92.5, C92.6, C92.8, C93.0, C94.0, C94.2), Average Number of New Cases per Year and Age-Specific Incidence Rates per 100,000 Population, UK, 2014-2016

95% LCL and 95% UCL are the 95% lower and upper confidence limits Open a glossary item around the AS Rate Open a glossary item
 

For acute myeloid leukaemia, like most cancer types, incidence increases with age. This largely reflects cell DNA damage accumulating over time. Damage can result from biological processes or from exposure to risk factors. A drop or plateau in incidence in the oldest age groups often indicates reduced diagnostic activity perhaps due to general ill health.

References

  1. Data were provided by the National Cancer Registration and Analysis Service (part of Public Health England), on request through the Office for Data Release, August 2018. Similar data can be found here: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases
  2. Data were provided by ISD Scotland on request, April 2018. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, February 2019. Similar data can be found here: http://www.wcisu.wales.nhs.uk.
  4. Data were provided by the Northern Ireland Cancer Registry on request, April 2018. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 2014-2016, ICD-10 C92.0, C92.4, C92.5, C92.6, C92.8, C93.0, C94.0, C94.2.

Last reviewed:

Acute myeloid leukaemia European age-standardised (AS) Open a glossary item incidence rates for females and males combined increased by 29% in the UK between 1993-1995 and 2014-2016.[1-4] The increase was of a similar size in females and males.

For females, acute myeloid leukaemia AS incidence rates in the UK increased by 23% between 1993-1995 and 2014-2016. For males, acute myeloid leukaemia AS incidence rates in the UK increased by 30% between 1993-1995 and 2014-2016.

Over the last decade in the UK (between 2004-2006 and 2014-2016), acute myeloid leukaemia AS incidence rates for females and males combined increased by 8%. In females AS incidence rates remained stable, and in males rates increased by 8%.

Acute Myeloid Leukaemia (ICD-10 C92.0, C92.4, C92.5, C92.6, C92.8, C93.0, C94.0, C94.2), European Age-Standardised Incidence Rates, UK, 1993-2016

Acute myeloid leukaemia incidence rates have varied between age groups in females and males combined in the UK since the early 1990s.[1-4] Rates in 0-24s have remained stable, in 25-49s have remained stable, in 50-59s have remained stable, in 60-69s have increased by 12%, in 70-79s have increased by 41%, and in 80+s have increased by 70%.

Acute Myeloid Leukaemia (ICD-10 C92.0, C92.4, C92.5, C92.6, C92.8, C93.0, C94.0, C94.2), European Age-Standardised Incidence Rates, By Age, UK, 1993-2016

For acute myeloid leukaemia there are few established risk factors, therefore increasing incidence in the 1980s and 1990s may largely reflect improvements in diagnosis and data recording.

References

  1. Data were provided by the National Cancer Registration and Analysis Service (part of Public Health England), on request through the Office for Data Release, August 2018. Similar data can be found here: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases
  2. Data were provided by ISD Scotland on request, April 2018. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, February 2019. Similar data can be found here: http://www.wcisu.wales.nhs.uk.
  4. Data were provided by the Northern Ireland Cancer Registry on request, April 2018. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 1993-2016, ICD-10 C92.0, C92.4, C92.5, C92.6, C92.8, C93.0, C94.0, C94.2.

Last reviewed:

There is evidence for a small association between acute myeloid leukaemia (AML) incidence and deprivation for males in England, but there is no evidence for an association for females.[1]  England-wide data for 2006-2010 show European age-standardised Open a glossary item incidence rates are 15% higher for males living in the most deprived areas compared with the least deprived, but for females the rates are similar for those living in the least and most deprived areas.[1]

Acute Myeloid Leukaemia (C920, C924, C925, C930, C940, C942), European Age-Standardised Incidence Rates by Deprivation Quintile, England, 2006-2010

For males diagnosed with acute myeloid leukaemia the deprivation gradient has gone from having higher incidence rates in the less deprived in 1996-2000 to higher incidence rates in the more deprived in 2006-2010. The estimated deprivation gradient in acute myeloid leukaemia, between females living in the most and least deprived areas in England has not changes in the period 1996-2010.

It has been estimated that there would have been around 90 fewer cancer cases each year in England during 2006-2010 if all people experienced the same incidence rates as the least deprived.[1]

References

  1. Cancer Research UK and National Cancer Intelligence Network. Cancer by deprivation in England: Incidence, 1996-2010, Mortality, 1997-2011. London: NCIN; 2014.

About this data

Data is for: England, 2006-2010, ICD-10 C920, C924, C925, C930, C940, C942

Deprivation gradient statistics were calculated using incidence data for 2006-2010. The deprivation quintiles were calculated using the Income domain scores from the Index of Multiple Deprivation (IMD) from the following years: 2004, 2007 and 2010. Full details on the data and methodology can be found in the Cancer by Deprivation in England NCIN report.

Last reviewed:

An estimated 6,100 people who had been diagnosed with acute myeloid leukaemia (AML) between 1991 and 2010 were alive in the UK at the end of 2010.[1]

References

  1. Macmillan Cancer Support and National Cancer Registration and Analysis Service. Cancer Prevalence UK Data Tables. London: NCRAS; 2015.

About this data

Data is for: Great Britain (1991-2010) and Northern Ireland (1993-2010), ICD-10 C92.0, C92.4, C92.5, C93.0, C94.0, C94.2.

Last reviewed:

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