Chronic lymphocytic leukaemia (CLL) incidence statistics

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Cases

New cases of chronic lymphocytic leukaemia each year, 2016-2018 average, UK.

 

Proportion of all cases

Percentage chronic lymphocytic leukaemia is of total cancer cases, 2016-2018, UK

 

Age

Peak rate of chronic lymphocytic leukaemia cases, 2016-2018, UK

Trend over time

Change in chronic lymphocytic leukaemia incidence rates since the early 1990s, UK

 

Chronic lymphocytic leukaemia accounted for 1% of all new cancer cases in the UK in 2016-2018.[1-4]

In females in the UK, chronic lymphocytic leukaemia accounted for less than 1% of all new female cancer cases. In males in the UK, it accounted for 1% of all new male cancer cases).

37% of chronic lymphocytic leukaemia cases in the UK are in females, and 63% are in males.

Chronic lymphocytic leukaemia incidence rates (European age-standardised (AS) rate Open a glossary item) for persons are significantly higher than the UK average in England, significantly lower than the UK average in Scotland and Wales, and similar to the UK average in Northern Ireland.

For chronic lymphocytic leukaemia, there are few established risk factors therefore differences between countries largely reflect differences in diagnosis and data recording.

Chronic Lymphocytic Leukaemia (C91.1), Average Number of New Cases Per Year, Crude and European Age-Standardised (AS) Incidence Rates per 100,000 Population, UK, 2016-2018

  England Scotland Wales Northern Ireland UK
Female Cases 1,240 70 59 41 1,410
Crude Rate 4.4 2.5 3.7 4.3 4.2
AS Rate 4.4 2.5 3.4 4.8 4.2
AS Rate - 95% LCL 4.3 2.1 2.9 3.9 4.1
AS Rate - 95% UCL 4.6 2.8 3.9 5.6 4.3
Male Cases 2,091 140 95 67 2,393
Crude Rate 7.6 5.3 6.1 7.3 7.3
AS Rate 8.8 5.9 6.4 9.1 8.5
AS Rate - 95% LCL 8.6 5.3 5.6 7.8 8.3
AS Rate - 95% UCL 9.0 6.4 7.1 10.3 8.6
Persons Cases 3,331 211 153 108 3,803
Crude Rate 6.0 3.9 4.9 5.8 5.8
AS Rate 6.5 4.0 4.8 6.7 6.2
AS Rate - 95% LCL 6.3 3.7 4.3 6.0 6.0
AS Rate - 95% UCL 6.6 4.3 5.2 7.5 6.3

95% LCL and 95% UCL are the 95% lower and upper confidence limits around the AS Rate Open a glossary item
 

References

  1. Data were provided by the National Cancer Registration and Analysis Service (part of Public Health England), on request through the Office for Data Release, July 2021. Similar data can be found here: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases
  2. Data were provided by ISD Scotland on request, April 2020. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications.
  3. Data were published by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales https://phw.nhs.wales/services-and-teams/welsh-cancer-intelligence-and-surveillance-unit-wcisu/cancer-incidence-in-wales-2002-2018/, March 2021.
  4. Data were provided by the Northern Ireland Cancer Registry on request, May 2020. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 2016-2018, ICD-10 C91.1

Last reviewed:

Chronic lymphocytic leukaemia incidence is strongly related to age, with the highest incidence rates being in older people. In the UK in 2016-2018, on average each year 4 in 10 new cases (40%) were in people aged 75 and over.[1-4]

Age-specific incidence rates rise from around age 45-49 more steeply in males and more gradually in females. The highest rates are in in the 85 to 89 age group for females and the 90+ age group for males.

Incidence rates are significantly lower in females than males in a number of (mainly older) age groups. The gap is widest at age 50 to 54, when the age-specific incidence rate is 2.7 times lower in females than males.

Chronic lymphocytic leukaemia (C91.1), Average Number of New Cases per Year and Age-Specific Incidence Rates per 100,000 Population, UK, 2016-2018

For chronic lymphocytic leukaemia, like most cancer types, incidence increases with age. This largely reflects cell DNA damage accumulating over time. Damage can result from biological processes or from exposure to risk factors. A drop or plateau in incidence in the oldest age groups often indicates reduced diagnostic activity perhaps due to general ill health.

See also

Chronic lymphocytic leukaemia mortality statistics by age

Leukaemia (all subtypes combined) incidence statistics

Cancer incidence statistics by age for all cancers

References

  1. Data were provided by the National Cancer Registration and Analysis Service (part of Public Health England), on request through the Office for Data Release, July 2021. Similar data can be found here: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases
  2. Data were provided by ISD Scotland on request, April 2020. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications.
  3. Data were published by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales https://phw.nhs.wales/services-and-teams/welsh-cancer-intelligence-and-surveillance-unit-wcisu/cancer-incidence-in-wales-2002-2018/, March 2021.
  4. Data were provided by the Northern Ireland Cancer Registry on request, May 2020. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 2016-2018, ICD-10 C91.1.

Last reviewed:

Chronic lymphocytic leukaemia European age-standardised (AS) Open a glossary item incidence rates for females and males combined increased by 17% in the UK between 1993-1995 and 2015-2017.[1-4] The increase was of a similar size in females and males.

For females, chronic lymphocytic leukaemia AS incidence rates in the UK increased by 14% between 1993-1995 and 2015-2017. For males, chronic lymphocytic leukaemia AS incidence rates in the UK increased by 11% between 1993-1995 and 2015-2017.

Over the last decade in the UK (between 2005-2007 and 2015-2017), chronic lymphocytic leukaemia AS incidence rates for females and males combined increased by 9%. In females AS incidence rates remained stable, and in males rates increased by 7%.

Chronic Lymphocytic Leukaemia (ICD-10 C91.1), European Age-Standardised Incidence Rates, UK, 1993-2017

Chronic lymphocytic leukaemia incidence rates have increased overall in most broad adult age groups in females and males combined in the UK since the early 1990s, but have remained stable in some.[1-4] Rates in 25-49s have increased by 46%, in 50-59s have increased by 25%, in 60-69s have increased by 26%, in 70-79s have increased by 22%, and in 80+s have remained stable.

Chronic Lymphocytic Leukaemia (ICD-10 C91.1), European Age-Standardised Incidence Rates, By Age, UK, 1993-2017

For chronic lymphocytic leukaemia there are few established risk factors, therefore increasing incidence in the 1980s and 1990s may largely reflect improvements in diagnosis and data recording.

References

  1. Data were provided by the National Cancer Registration and Analysis Service (part of Public Health England), on request through the Office for Data Release, November 2019. Similar data can be found here: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases
  2. Data were provided by ISD Scotland on request, April 2019. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, December 2019. Similar data can be found here: http://www.wcisu.wales.nhs.uk.
  4. Data were provided by the Northern Ireland Cancer Registry on request, May 2019. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 1993-2017, ICD-10 C91.1.

Last reviewed:

Chronic lymphocytic leukaemia incidence rates (European age-standardised (AS) rates Open a glossary item) in England in females are similar in the most deprived quintile compared with the least, and in males are similar in the most deprived quintile compared with the least (2013-2017).[1]

See also

Data table: Cancer incidence rates and excess cases by cancer type in England

Incidence by deprivation for all cancer types combined

Chronic lymphocytic leukaemia mortality by deprivation  (not directly comparable with incidence by deprivation)

Cancer incidence by deprivation for Scotland

Cancer incidence by deprivation for Wales

Cancer incidence by deprivation for Northern Ireland

References

  1. Calculated by the Cancer Intelligence Team at Cancer Research UK, April 2020. Based on method reported in National Cancer Intelligence Network Cancer by Deprivation in England Incidence, 1996-2010 Mortality, 1997-2011 . Using cancer incidence data 2013-2017 (Public Health England) and population data 2013-2017 (Office for National Statistics) by Indices of Multiple Deprivation 2015 income domain quintile, cancer type, sex, and five-year age band.

About this data

Data is for England, 2013-2017, ICD-10 C91.1.

Last reviewed:

An estimated 20,200 people who had been diagnosed with chronic lymphocytic leukaemia (CLL) between 1991 and 2010 were alive in the UK at the end of 2010.[1]

See also

Chronic lymphocytic leukaemia (CLL) incidence statistics by sex and UK country

What is prevalence?

References

  1. Macmillan Cancer Support and National Cancer Registration and Analysis Service. Cancer Prevalence UK Data Tables. London: NCRAS; 2015.

About this data

Data is for: UK (1991-2010) and Northern Ireland (1993-2010), ICD-10 C911

Last reviewed:

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