Chronic lymphocytic leukaemia (CLL) incidence statistics

Cases

New cases of chronic lymphocytic leukaemia, 2015, UK

 

Proportion of all cases

Percentage chronic lymphocytic leukaemia is of total cancer cases, 2015, UK

 

Age

Peak rate of chronic lymphocytic leukaemia cases, 2013-2015, UK

 

 

Trend over time

Change in chronic lymphocytic leukaemia cancer incidence rates since the early 1990s, UK

Chronic lymphocytic leukaemia is not among the 20 most common cancers in the UK, accounting for 1% of all new cancer cases (2015).[1-4]

In males in the UK, chronic lymphocytic leukaemia is not among the 20 most common cancers (1% of all new male cancer cases). In females in the UK it is not among the 20 most common cancers (less than 1% of all new female cancer cases).

63% of chronic lymphocytic leukaemia cases in the UK are in males, and 37% are in females.

Chronic lymphocytic leukaemia incidence rates (European age-standardised (AS) rates Open a glossary item ) for persons are significantly higher than the UK average in Wales, significantly lower than the UK average in Northern Ireland and Scotland, and similar to the UK average in England.

Chronic Lymphocytic Leukaemia (C91.1), Number of New Cases, Crude and European Age-Standardised (AS) Incidence Rates per 100,000 Population, UK, 2015

  England Scotland Wales Northern Ireland UK
Male Cases 2,026 110 161 29 2,326
Crude Rate 7.5 4.2 10.6 3.2 7.3
AS Rate 9.0 4.9 11.3 4.3 8.6
AS Rate - 95% LCI 8.6 4.0 9.6 2.7 8.3
AS Rate - 95% UCI 9.3 5.9 13.0 5.8 9.0
Female Cases 1,226 49 79 29 1,383
Crude Rate 4.4 1.8 5.0 3.1 4.2
AS Rate 4.5 1.7 4.5 3.4 4.3
AS Rate - 95% LCI 4.3 1.3 3.5 2.1 4.0
AS Rate - 95% UCI 4.8 2.2 5.6 4.6 4.5
Persons Cases 3,252 159 240 58 3,709
Crude Rate 5.9 3.0 7.7 3.1 5.7
AS Rate 6.5 3.1 7.6 3.8 6.2
AS Rate - 95% LCI 6.3 2.7 6.7 2.8 6.0
AS Rate - 95% UCI 6.8 3.6 8.6 4.8 6.4

95% LCL and 95% UCL are the 95% lower and upper confidence limits Open a glossary item  around the AS Rate Open a glossary item
 

For chronic lymphocytic leukaemia, there are few established risk factors therefore differences between countries largely reflect differences in diagnosis and data recording.

References

  1. Data were provided by the Office for National Statistics on request, July 2017. Similar data can be found here: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases.
  2. Data were provided by ISD Scotland on request, August 2017. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, October 2017. Similar data can be found here: http://www.wcisu.wales.nhs.uk.
  4. Data were provided by the Northern Ireland Cancer Registry on request, July 2017. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 2015, ICD-10 C91.1.

Last reviewed:

Chronic lymphocytic leukaemia incidence is strongly related to age, with the highest incidence rates being in older people. In the UK in 2013-2015, on average each year more than 4 in 10 (43%) of new cases were in people aged 75 and over.[1-4

Age-specific incidence rates rise steeply from around age 40-44. The highest rates are in the 90+ age group for males and females.

Incidence rates are significantly higher in males than females in a number of (mainly older) age groups. The gap is widest at age 30 to 34, when the age-specific incidence rate is 7.1 times higher in males than females.

Chronic Lymphocytic Leukaemia (C91.1), Average Number of New Cases per Year and Age-Specific Incidence Rates per 100,000 Population, UK, 2013-2015

95% LCL and 95% UCL are the 95% lower and upper confidence limits Open a glossary item around the AS Rate Open a glossary item
 

For chronic lymphocytic leukaemia, like most cancer types, incidence increases with age. This largely reflects cell DNA damage accumulating over time. Damage can result from biological processes or from exposure to risk factors. A drop or plateau in incidence in the oldest age groups often indicates reduced diagnostic activity perhaps due to general ill health.

References

  1. Data were provided by the Office for National Statistics on request, July 2017. Similar data can be found here: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases.
  2. Data were provided by ISD Scotland on request, August 2017. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, October 2017. Similar data can be found here: http://www.wcisu.wales.nhs.uk.
  4. Data were provided by the Northern Ireland Cancer Registry on request, July 2017. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 2013-2015, ICD-10 C91.1.

Last reviewed:

Chronic lymphocytic leukaemia European age-standardised (AS Open a glossary item) incidence rates for males and females combined increased by 18% in the UK between 1993-1995 and 2013-2015.[1-4] The increase was of a similar size in males and females.

For males, chronic lymphocytic leukaemia AS incidence rates in the UK increased by 13% between 1993-1995 and 2013-2015. For females, chronic lymphocytic leukaemia AS incidence rates in the UK increased by 15% between 1993-1995 and 2013-2015.

Over the last decade in the UK (between 2003-2005 and 2013-2015), chronic lymphocytic leukaemia AS incidence rates for males and females combined increased by 8%. In males AS incidence rates increased by 6%, and in females rates increased by 8%.

Chronic Lymphocytic Leukaemia (C91.1), European Age-Standardised Incidence Rates, UK, 1993-2015

Chronic lymphocytic leukaemia incidence rates have increased overall in some broad age groups in males and females combined in the UK since the early 1990s, but have remained stable in others.[1-4] Rates in 0-24s have remained stable, in 25-49s have increased by 32%, in 50-59s have increased by 22%, in 60-69s have increased by 25%, in 70-79s have increased by 22%, and in 80+s have remained stable.

Chronic Lymphocytic Leukaemia (C91.1), European Age-Standardised Incidence Rates, By Age, UK, 1993-2015

For chronic lymphocytic leukaemia there are few established risk factors, therefore increasing incidence in the 1980s and 1990s may largely reflect improvements in diagnosis and data recording.

References

  1. Data were provided by the Office for National Statistics on request, July 2017. Similar data can be found here: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases.
  2. Data were provided by ISD Scotland on request, August 2017. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, October 2017. Similar data can be found here: http://www.wcisu.wales.nhs.uk.
  4. Data were provided by the Northern Ireland Cancer Registry on request, July 2017. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 1993-2014, ICD-10 C91.1

Last reviewed:

There is no evidence for an association between chronic lymphocytic leukaemia (CLL) incidence and deprivation for either males or females in England.[1] England-wide data for 2006-2010 show European age-standardised Open a glossary item incidence rates are similar for both males and females living in the most deprived areas compared with the least deprived.[1]

Chronic Lymphocytic Leukaemia (C91.1), European Age-Standardised Incidence Rates by Deprivation Quintile, England, 2006-2010

The estimated deprivation gradient in CLL incidence between people living in the most and least deprived areas in England has not changed in the period 1996-2010.[1]

References

  1. Cancer Research UK and National Cancer Intelligence Network. Cancer by deprivation in England: Incidence, 1996-2010, Mortality, 1997-2011. London: NCIN; 2014.

About this data

Data is for: England, 2006-2010, ICD-10 C91.1

Deprivation gradient statistics were calculated using incidence data for 2006-2010. The deprivation quintiles were calculated using the Income domain scores from the Index of Multiple Deprivation (IMD) from the following years: 2004, 2007 and 2010. Full details on the data and methodology can be found in the Cancer by Deprivation in England NCIN report.

Last reviewed:

An estimated 20,200 people who had been diagnosed with chronic lymphocytic leukaemia (CLL) between 1991 and 2010 were alive in the UK at the end of 2010.[1]

References

  1. Macmillan Cancer Support and National Cancer Registration and Analysis Service. Cancer Prevalence UK Data Tables. London: NCRAS; 2015.

About this data

Data is for: UK (1991-2010) and Northern Ireland (1993-2010), ICD-10 C911

Last reviewed:

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