
"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This trial is looking at removing the original (primary) area of cancer in the bowel or back passage before chemotherapy. It is recruiting people with advanced bowel cancer. This trial is supported by Cancer Research UK.
Doctors usually treat bowel cancer that has spread (metastasised) with chemotherapy. But if the original (primary) cancer starts to cause symptoms, such as pain or sickness, you may need an operation to remove it.
Symptoms can sometimes start during or after chemotherapy. The doctors in this trial think that it might be useful to remove the area of primary bowel cancer before it causes symptoms and before chemotherapy. But they are not sure yet. It is important to find out because doctors do not want to put people through unnecessary surgery.
The aims of this trial are to find out
You can enter this trial if
You cannot enter this trial if
500 people will take part in this trial. This is a randomised trial. The people taking part will be put into 2 different groups by computer. Neither you nor your doctor can decide which group you are in.
If you are in group 1 you have standard chemotherapy for advanced bowel cancer. If your primary bowel cancer causes symptoms and you are already taking part in the trial, then you may go on to have surgery if your doctors think it may help you.
If you are in group 2 you have surgery to remove your original area of bowel cancer. You will start standard chemotherapy for advanced bowel cancer 8 weeks later.
The type of standard chemotherapy you have in this trial depends on the hospital you go to. Your trial doctor will be able to tell you more about this.
You fill out a short questionnaire
The questionnaire will ask about how you have been feeling. It is called a quality of life questionnaire.
As part of the trial, the researchers will ask your permission to get a sample of tissue that was removed when you had a biopsy. And they will ask if they can keep another sample of tissue if you have bowel surgery. The samples will be stored safely and may be used in the future, but only for research purposes. If you do not want to give these samples for research, you don’t have to. You can still take part in the trial.
You see the doctors and have some tests before you start treatment. The tests include
If you have surgery you will probably be in hospital for between 1 and 3 weeks. You will also need a few weeks to recover from the operation.
When you finish treatment you will go to the hospital for routine check ups with your doctor every 3 months, for up to up to 2 years.
All treatments have side effects. The most common side effects of chemotherapy include
The most common side effects of bowel surgery include
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Mr Austin Obichere
Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
This is Cancer Research UK trial number CRUK/08/038.
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”