“I was keen to go on a clinical trial. I wanted to try new cancer treatments and hopefully help future generations.”
A trial looking at the timing of chemotherapy and radiotherapy after breast cancer surgery (SECRAB)
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This trial looked at the timing of radiotherapy and chemotherapy after surgery for early breast cancer. This trial was supported by Cancer Research UK.
In this trial some women had radiotherapy and chemotherapy at the same time, and some had chemotherapy first and then radiotherapy. Doctors wanted to find out if the timing of radiotherapy makes any difference to the risk of the cancer coming back, or to quality of life.
The aim of this trial was to find out
- Which treatment was best at stopping the cancer coming back
- More about the side effects
- How it affected quality of life
Summary of results
The trial team found that having chemotherapy and radiotherapy together was better at stopping breast cancer coming back than having chemotherapy and then radiotherapy.
This trial recruited 2,296 women with early stage breast cancer. They all had surgery followed by chemotherapy and radiotherapy.
- 1,146 women had radiotherapy after chemotherapy (sequential treatment)
- 1,150 women had radiotherapy between 2 cycles of chemotherapy (synchronous treatment)
The research team looked at the number of cancers that had come back in the breast area 5 years after treatment. This is called local recurrence. They found that the cancer came back in
- Just over 5 out of every hundred women (5.1%) who had sequential treatment
- Just under 3 out of every hundred women (2.8%) who had synchronous treatment
They also looked at side effects and quality of life. The women who had radiotherapy between cycles of chemotherapy had more side effects from radiotherapy (such as sore skin). But there was no difference in the results of the quality of life questionnaires between the 2 groups.
The research team concluded that having radiotherapy and chemotherapy at the same time does help stop breast cancer coming back.
We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists (
How to join a clinical trial
Cancer Research UK
NIHR Clinical Research Network: Cancer
This is Cancer Research UK trial number CRUK/98/001.