Ovarian cancer incidence statistics

Cases

New cases of ovarian cancer, 2014, UK

Proportion of all cases

Percentage ovarian cancer is of total cancer cases, 2014, UK

 

Age

Peak rate of ovarian cancer cases, 2012-2014, UK

Trend over time

Ovarian cancer incidence rates have remained stable since the early 1990s, UK

Ovarian cancer is the sixth most common cancer among females in the UK (2014), accounting for 4% of all new cases of cancer in females.[1-4]

In 2014, there were 7,378 new cases of ovarian cancer in the UK.[1-4] The crude incidence rate Open a glossary item shows that there are 23 new ovarian cancer cases for every 100,000 females in the UK.

The European age-standardised incidence rates Open a glossary item (AS rates) do not differ significantly between the constituent countries of the UK.

Ovarian Cancer (C56-C57.4), Number of New Cases, Crude and European Age-Standardised (AS) Incidence Rates per 100,000 Population, Females, UK, 2014

England Wales Scotland Northern Ireland UK
Cases 6,201 372 607 198 7,378
Crude Rate 22.5 23.7 22.1 21.1 22.5
AS Rate 23.5 23.0 21.7 23.2 23.3
AS Rate - 95% LCL 22.9 20.7 20.0 20.0 22.7
AS Rate - 95% UCL 24.1 25.4 23.4 26.4 23.8

95% LCL and 95% UCL are the 95% lower and upper confidence limits Open a glossary item around the AS rate Open a glossary item.

For ovarian cancer, like most cancer types, differences between countries largely reflect risk factor prevalence in years past.

References

  1. Data were provided by the Office for National Statistics on request, June 2016. Similar data can be found here: http://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases
  2. Data were provided by ISD Scotland on request, May 2016. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, June 2016. Similar data can be found here: http://www.wcisu.wales.nhs.uk
  4. Data were provided by the Northern Ireland Cancer Registry on request, May 2016. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/

About this data

Data is for: UK, 2014, ICD10 C56-57.4

Last reviewed:

Ovarian cancer incidence is strongly related to age, with the highest incidence rates being in older females. In the UK in 2012-2014, on average each year more than half (53%) of cases were diagnosed in females aged 65 and over.[1-4]

Age-specific incidence rates rise sharply from around age 30-34, peak in those aged 75-79, and subsequently drop sharply.[1-4]

Ovarian Cancer (C56-C57.4), Average Number of New Cases per Year and Age-Specific Incidence Rates per 100,000 Population, Females, UK, 2012-2014

For ovarian cancer, like most cancer types, incidence increases with age. This largely reflects cell DNA damage accumulating over time. Damage can result from biological processes or from exposure to risk factors. A drop or plateau in incidence in the oldest age groups often indicates reduced diagnostic activity perhaps due to general ill health.

References

  1. Data were provided by the Office for National Statistics on request, June 2016. Similar data can be found here: http://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases.
  2. Data were provided by ISD Scotland on request, May 2016. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, June 2016. Similar data can be found here: http://www.wcisu.wales.nhs.uk.
  4. Data were provided by the Northern Ireland Cancer Registry on request, May 2016. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 2012-2014, ICD-10 C56-57.4

Last reviewed:

Ovarian cancer incidence rates have remained stable in females in the UK since the early 1990s.[1-4] This includes an increase followed by a decrease during this time. Ovarian cancer incidence rates increased by 14% in Great Britain between 1979-1981 and 1991-1993.[1-3]

European age-standardised (AS) Open a glossary item incidence rates increased by 10% between 1993-1995 and 1997-1999, and have since decreased by 8% (between 1997-1999 and 2012-2014).

Over the last decade in the UK (between 2003-2005 and 2012-2014), ovarian cancer AS incidence rates in females have decreased by 4%.[1-4]

Ovarian Cancer (C56-C57.4), European Age-Standardised Incidence Rates, Females, UK, 1993-2014

Ovarian cancer incidence rates have increased overall for most of the broad age groups in the UK since the early 1990s but have decreased in females aged 50-59 and 60-69. The largest increase has been in females aged 0-24, with European age standardised (AS) incidence rates increasing by 85% between 1993-1995 and 2012-2014. The largest decrease has been in females aged 50-59, with rates decreasing by 15% between 1993-1995 and 2012-2014.[1-4]

Ovarian Cancer (C56-C57.4), European Age-Standardised Incidence Rates, by Age, Females, UK, 1993-2014​

For ovarian cancer, like most cancer types, incidence trends largely reflect changing prevalence of risk factors and improvements in diagnosis and data recording. Recent incidence trends are influenced by risk factor prevalence in years past, and trends by age group reflect risk factor exposure in birth cohorts.

References

  1. Data were provided by the Office for National Statistics on request, June 2016. Similar data can be found here: http://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases
  2. Data were provided by ISD Scotland on request, May 2016. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/ 
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, June 2016. Similar data can be found here: http://www.wcisu.wales.nhs.uk
  4. Data were provided by the Northern Ireland Cancer Registry on request, May 2016. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/

About this data

Data is for UK, 1993-2014, ICD-10 C55-C57.4

Last reviewed:

Overall stage at diagnosis

A high proportion (85-88%) of ovarian cancer cases in England and Northern Ireland have stage at diagnosis recorded.[1,2]

More females with a known stage are diagnosed at a late stage (55-58% are diagnosed at stage III or IV), than an early stage (42-45% are diagnosed at stage I or II). Between 17% and 21% of females have metastases at diagnosis (stage IV).[1,2]

The stage distribution for each cancer type will reflect many factors including how the cancer type develops, the way symptoms appear, public awareness of symptoms, how quickly a person goes to see their doctor and how quickly the cancer is recognised and diagnosed by a doctor. It might also relate to whether a national screening programme that can detect early stage disease exists for that cancer type, along with the extent of uptake of that programme.

A cancer type associated with a large proportion of early stage diagnoses could be one that is more likely to be symptomatic at an earlier stage of development, with recognisable symptoms rather than more generic ones.

Ovarian Cancer (C56), Proportion of Cases Diagnosed at Each Stage, All Ages, England 2014 and Northern Ireland 2010-2014

Data should not be compared between countries due to differences in time periods and possible differences in recording of stage at diagnosis.
 

Stage at diagnosis by deprivation

Late stage at diagnosis of ovarian cancer is not associated with deprivation in England.[3]

Stage at diagnosis by age

Late stage at diagnosis of ovarian cancer is more common in women aged 80+ in England (77% diagnosed at stage III or IV), compared to those aged 60-79 (66% diagnosed at stage III or IV) and compared to younger women aged 15-59 (39% diagnosed at stage III or IV).[3]

Late stage ovarian cancer is also more common in women aged 60-79 in England (66% diagnosed at stage III or IV) versus those aged 15-59 (39% diagnosed at stage III or IV).[3]

These patterns by deprivation, age and sex are probably not explained by other demographic differences.[4]

References

  1. National Cancer Intelligence Network. Stage Breakdown by CCG 2014. London: NCIN; 2016.
  2. Northern Ireland Cancer Registry, Queens University Belfast, Incidence by stage 2010-2014. Belfast: NICR; 2016.
  3. National Cancer Registration and Analysis Service. Routes to diagnosis of cancer by stage 2012-2013 workbook. London: NCRAS; 2016.
  4. Lyratzopoulos G, Abel G, Brown C, et al. Socio-demographic inequalities in stage of cancer diagnosis: evidence from patients with female breast, lung, colon, rectal, prostate, renal, bladder, melanoma, ovarian and endometrial cancer. Annals of Oncology, 2012:843-50.

About this data

Data is for:  England 2014, Northern Ireland 2010-2014, ICD-10 C56 (overall stage at diagnosis) and England, 2012-2013, ICD-10 C56-C57 (stage at diagnosis by deprivation, age, sex, and ethnicity)

Data is not comparable between countries due to differences in time periods and possible differences in how countries record stage at diagnosis.

The proportions of patients diagnosed late only include cases with a known stage at diagnosis and are not adjusted for other demographics differences (e.g. age, sex, ethnicity) unless stated otherwise.

Last reviewed:

80-90% of ovarian malignancies are epithelial  in origin, with the most common type in the UK being serous carcinomas.[1-3] Other rarer subtypes include germ cell tumours Open a glossary item, which tend to occur in pre-menopausal women and are very chemo-sensitive (and hence treatable). It is thought that most histologies share common risk factors, with the probable exception of mucinous carcinomas.[1,4]

The most striking international difference occurs in Japan, which has lower rates of ovarian cancer than in Europe.[5] Some of this variation may be explained by geographical differences in histologies, since Japan has a higher percentage of clear cell adenocarcinomas Open a glossary item (20-25%) compared with other Asian or Western countries (5-10%).[6]

References

  1. Granstrom C, Sundquist J, Hemminki K. Population attributable fractions for ovarian cancer in Swedish women by morphological type. Br J Cancer 2008;98:199-205.
  2. DeVita VT, Lawrence TS, Rosenberg SA, eds. Cancer: Principles and Practice of Oncology. 8th edition. Philadephia, USA: Lippincott Williams & Wilkins, 2008.
  3. McCluggage WG. My approach to and thoughts on the typing of ovarian carcinomas. Journal of Clinical Pathology 2008;61:152-63.
  4. Purdie DM, Webb PM, Siskind V, et al. The different etiologies of mucinous and nonmucinous epithelial ovarian cancers. Gynecol Oncol 2003;88:S145-8.
  5. Ferlay J, Shin HR, Bray F, et al. GLOBOCAN 2008 v1.2, Cancer Incidence and Mortality Worldwide. IARC Cancerbase No,10 [Internet] Lyon, France: International Agency for Research on Cancer, 2010. Available from: http://globocan.iarc.fr.
  6. Ushijima K. Current status of gynecologic cancer in Japan. J Gynecol Oncol 2009;20:67-71.
Last reviewed:

Ovarian cancer incidence rates are projected to rise by 15% in the UK between 2014 and 2035, to 32 cases per 100,000 females by 2035.[1]

Ovarian cancer (C56-C57.4), Observed and Projected Age-Standardised Incidence Rates, by Sex, UK, 1979-2035

It is projected that 10,501 cases of ovarian cancer will be diagnosed in the UK in 2035.

References

  1. Smittenaar CR, Petersen KA, Stewart K, Moitt N. Cancer Incidence and Mortality Projections in the UK Until 2035. Brit J Cancer 2016.

About this data

Data is for: UK, 1979-2014 (observed), 2015-2035 (projected), ICD-10 C56-C57.4

Projections are based on observed incidence and mortality rates and therefore implicitly include changes in cancer risk factors, diagnosis and treatment. It is not possible to assess the statistical significance of changes between 2014 (observed) and 2035 (projected) figures. Confidence intervals are not calculated for the projected figures. Projections are by their nature uncertain because unexpected events in future could change the trend. It is not sensible to calculate a boundary of uncertainty around these already uncertain point estimates. Changes are described as 'increase' or 'decrease' if there is any difference between the point estimates.

More on projections methodology

Last reviewed:

The lifetime risk of developing ovarian cancer is 1 in 52 for women, in 2012 in the UK.[1]

The lifetime risk for ovarian cancer has been calculated to account for the possibility that someone can have more than one diagnosis of ovarian cancer over the course of their lifetime (‘Adjusted for Multiple Primaries’ (AMP) method).[2]

References

  1. Lifetime risk estimates calculated by the Statistical Information Team at Cancer Research UK. Based on data provided by the Office of National Statistics, ISD Scotland, the Welsh Cancer Intelligence and Surveillance Unit and the Northern Ireland Cancer Registry, on request, December 2013 to July 2014.
  2. Sasieni PD, Shelton J, Ormiston-Smith N, et al. What is the lifetime risk of developing cancer?: The effect of adjusting for multiple primaries. Br J Cancer, 2011. 105(3): p. 460-5.
Last reviewed:

There is no evidence for an association between ovarian cancer incidence and deprivation in England.[1] England-wide data for 2006-2010 show European age-standardised Open a glossary item incidence rates are similar for females living in the most deprived areas compared with the least deprived.[1]

Ovarian Cancer (C56-C57), European Age-Standardised Incidence Rates by Deprivation Quintile, Females, England, 2006-2010

The estimated deprivation gradient in ovarian cancer incidence between females living in the most and least deprived areas in England has not changed in the period 1996-2010.[1]

References

  1. Cancer Research UK and National Cancer Intelligence Network. Cancer by deprivation in England: Incidence, 1996-2010, Mortality, 1997-2011. London: NCIN; 2014.

About this data

Data is for UK, 2006-2010, ICD-10 CC56-C57

Deprivation gradient statistics were calculated using incidence data for 2006-2010. The deprivation quintiles were calculated using the Income domain scores from the Index of Multiple Deprivation (IMD) from the following years: 2004, 2007 and 2010. Full details on the data and methodology can be found in the Cancer by Deprivation in England NCIN report.

Last reviewed:

Age-standardised Open a glossary item rates for White females with ovarian cancer (ICD-10 C56 only) range from 17.4 to 18.1 per 100,000. Rates for Asian females are significantly lower, ranging from 9.2 to 15.5 per 100,000 and the rates for Black females are also significantly lower, ranging from 6.6 to 12.1 per 100,000.[1]

Ranges are given because of the analysis methodology used to account for missing and unknown data. For ovarian cancer, 28,023 cases were identified; 22% had no known ethnicity.

Last reviewed:

An estimated 41,000 women who had been diagnosed with ovarian cancer between 1991 and 2010 were alive in the UK at the end of 2010.[1]

References

  1. Macmillan Cancer Support and National Cancer Registration and Analysis Service. Cancer Prevalence UK Data Tables. London: NCRAS; 2015.

About this data

Data is for: Great Britain (1991-2010) and Northern Ireland (1993-2010), ICD-10 C56-57.4

Last reviewed:

Ovarian cancer (C56 only) is the fifth most common cancer in Europe for females, and the 13th most common cancer overall, with around 65,600 new cases diagnosed in 2012 (4% of female cases and 2% of the total). In Europe (2012), the highest World age-standardised Open a glossary item incidence rate for ovarian cancer are in Latvia; the lowest are in Albania. UK ovarian cancer incidence rates are estimated to be the ninth highest in Europe.[1] These data are broadly in line with Europe-specific data available elsewhere.[2]

Ovarian cancer (C56 only) is the seventh most common cancer worldwide for females, and the 18th most common cancer overall, with nearly 239,000 new cases diagnosed in 2012 (4% of female cases and 2% of the total). Ovarian cancer incidence rates are highest in Central and Eastern Europe and lowest in Western Africa, but this partly reflects varying data quality worldwide.[1]

Variation between countries may reflect different prevalence of risk factors, use of screening, and diagnostic methods.

References

  1. Ferlay J, Soerjomataram I, Ervik M, et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from:http://globocan.iarc.fr, accessed December 2013.
  2. Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, et al.Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012. European Journal of Cancer (2013) 49, 1374-1403.

About this data

Data is for: Europe and worldwide, 2012, ICD-10 C56 only

Last reviewed:

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