Laryngeal cancer incidence statistics

Cases

New cases of head and neck cancer, 2014, UK

Proportion of all cases

Percentage head and neck cancer is of total cancer cases, 2014, UK

Age

Peak rate of head and neck cancer cases, 2012-2014, UK

Trend since 1970s

Laryngeal cancer incidence rates have changed differently for each sex since the late 1970s, GB

 

Head and neck cancer is the eighth most common cancer in the UK (2014), accounting for 3% of all new cases. In males, it is the fourth most common cancer in the UK (4% of all male cases), whilst it is the 12th most common cancer in females in the UK (2% of all new cases).[1-4]

In 2014, there were 11,449 new cases of head and neck cancer in the UK: 7,918 (69%) in males and 3,531 (31%) in females, giving a male:female ratio of around 22:10.[1-4] The crude incidence rate Open a glossary item shows that there are 25 new head and neck cancer cases for every 100,000 males in the UK, and 11 for every 100,000 females.

For both sexes, the European age-standardised Open a glossary item incidence rates (AS rates) are significantly higher in Scotland compared with England. For males only, rates are also significantly higher in Wales compared with England.[1-4] Rates do not differ significantly between the other constituent countries of the UK for either sex.

Head and Neck Cancer (C00-C14, C30-C32), Number of New Cases, Crude and European Age-Standardised (AS) Incidence Rates per 100,000 Population, UK, 2014

England Wales Scotland Northern Ireland UK
Male Cases 6,398 448 852 220 7,918
Crude Rate 23.9 29.4 32.8 24.4 24.9
AS Rate 27.2 30.7 35.3 30.7 28.1
AS Rate - 95% LCL 26.5 27.9 32.9 26.6 27.5
AS Rate - 95% UCL 27.8 33.6 37.6 34.7 28.7
Female Cases 2,859 195 387 90 3,531
Crude Rate 10.4 12.4 14.1 9.6 10.8
AS Rate 10.8 11.8 13.9 10.9 11.2
AS Rate - 95% LCL 10.4 10.2 12.5 8.6 10.8
AS Rate - 95% UCL 11.2 13.5 15.3 13.1 11.5
Persons Cases 9,257 643 1,239 310 11,449
Crude Rate 17.0 20.8 23.2 16.8 17.7
AS Rate 18.5 20.7 23.9 20.0 19.2
AS Rate - 95% LCL 18.2 19.1 22.6 17.8 18.8
AS Rate - 95% UCL 18.9 22.3 25.3 22.2 19.5

95% LCL and 95% UCL are the 95% lower and upper confidence limits Open a glossary item around the AS Rate
 

For head and neck cancer, like most cancer types, differences between countries largely reflect risk factor prevalence in years past.

References

  1. Data were provided by the Office for National Statistics on request, June 2016. Similar data can be found here: http://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases.
  2. Data were provided by ISD Scotland on request, May 2016. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, June 2016. Similar data can be found here: http://www.wcisu.wales.nhs.uk.
  4. Data were provided by the Northern Ireland Cancer Registry on request, May 2016. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for: UK, 2014, ICD-10 C00-C14, C30-C32

Last reviewed:

Head and neck cancer incidence is strongly related to age, with the highest incidence rates being in older males and females. In the UK in 2012-2014, on average each year half (50%) cases were diagnosed in people aged 65 and over.[1-4]

For males, age-specific incidence rates rise sharply from around age 35-39, peak in the 70-74 age group, and subsequently drop before rising again to plateau in the 85-89 and 90+ age groups. For females, age-specific incidence rates rise gradually from around age 35-39, with the highest rate in the 90+ age group. Incidence rates are higher for males than for females aged 35-39 and over (this gap is not significant in younger age groups), and this gap is widest in the 55-59 age group, when the male: female incidence ratio of age-specific rates (to account for the different proportions of males to females in each age group) is around 28:10.[1-4]

Head and Neck Cancer (C00- C14, C30-C32), Average Number of New Cases per Year and Age-Specific Incidence Rates, UK, 2012-2014

For head and neck cancer, like most cancer types, incidence increases with age. This largely reflects cell DNA damage accumulating over time. Damage can result from biological processes or from exposure to risk factors. A drop or plateau in incidence in the oldest age groups often indicates reduced diagnostic activity perhaps due to general ill health.

References

  1. Data were provided by the Office for National Statistics on request, June 2016. Similar data can be found here: http://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases.
  2. Data were provided by ISD Scotland on request, May 2016. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, June 2016. Similar data can be found here: http://www.wcisu.wales.nhs.uk.
  4. Data were provided by the Northern Ireland Cancer Registry on request, May 2016. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 2012-2014, ICD-10 C00- C14, C30-C32

Last reviewed:

Laryngeal cancer incidence rates have decreased in males and females combined in Great Britain since the late 1970s.[1-3] However this includes a decrease in males and overall stable rates in females, and for both sexes there has been increase followed by a decrease during this time.[1-3]

For males, European age-standardised (AS) Open a glossary item incidence rates increased by 11% between 1979-1981 and 1992-1994, then fell by 24% between 1992-1994 and 2011-2013. The pattern is similar for females, with rates increasing by 17% between 1979-1981 and 1993-1995, then falling by 17% between 1993-1995 and 2011-2013.

Laryngeal Cancer (C32), European Age-Standardised Incidence Rates, Great Britain, 1979-2013

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

Over the last decade in the UK (between 2002-2004 and 2011-2013), larynx cancer AS incidence rates have remained stable in males and females combined, though this includes a decreased for males (7%) and stable rates in females.[1-4]

Laryngeal Cancer (C32), European Age-Standardised Incidence Rates, UK, 1993-2013

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

Larynx cancer incidence trends probably reflect changing prevalence of risk factors, with recent incidence trends influenced by risk factor prevalence in years past.

Laryngeal cancer incidence rates for males in Great Britain were similar in 2011-2013 compared with the late 1970s for those aged 70-79, however this included an increase followed by a decrease in this time.[1-3] Rates have overall decreased in males aged 25-49, 50-59, 60-69 and 80+, though this also includes an increase followed by a decrease. The largest increase was for males aged 70-79, for whom rates increased by 24% between 1979-1981 and 1992-1994, followed by a decrease of 25% between 1992-1994 and 2011-2013.

Laryngeal Cancer (C32), European Age-Standardised Incidence Rates, by Age, Males, Great Britain, 1979-2013

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

Laryngeal cancer European AS incidence rates for females in Great Britain were similar in 2011-2013 compared with the late 1970s for most age groups, though in some age groups this includes an increase followed by a decrease.[1-3] In females aged 70-79, rates increased by 47% between 1979-1981 and 1998-2000, then decreased by 28% between 1998-2000 and 2005-2007, and have since remained stable. In females aged 60-69 rates fluctuated but overall increased by 40% between 1979-1981 and 1988-1990, and subsequently decreased by 25% between 1988-1990 and 2011-2013.[1-3] Rates in females aged 50-59 have decreased by 26% since peaking in 1987-1989.[1-3]

Laryngeal Cancer (C32), European Age-Standardised Incidence Rates, by Age, Females, Great Britain, 1979-2013

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

References

  1. Data were provided by the Office for National Statistics on request, July 2015. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html.
  2. Data were provided by ISD Scotland on request, April 2015. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, February 2015. Similar data can be found here: http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=59080.  
  4. Data were provided by the Northern Ireland Cancer Registry on request, March 2015. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.  
Last reviewed:

Laryngeal cancer incidence rates are projected to fall by 17% in the UK between 2014 and 2035, to 4 cases per 100,000 people by 2035.[1] This includes a larger decrease for males than for females.

For males, laryngeal cancer European age standardised (AS) incidence rates in the UK are projected to fall by 22% between 2014 and 2035, to 7 cases per 100,000 by 2035.[1] For females, rates are projected to fall by 2% between 2014 and 2035, to 1 case per 100,000 by 2035.[1]

Laryngeal cancer (C32), Observed and Projected Age-Standardised Incidence Rates, by Sex, UK, 1979-2035

 

It is projected that 2,598 cases of laryngeal cancer (2,100 in males, 499 in females) will be diagnosed in the UK in 2035.

References

  1. Smittenaar CR, Petersen KA, Stewart K, Moitt N. Cancer Incidence and Mortality Projections in the UK Until 2035. Brit J Cancer 2016.

About this data

Data is for: UK, 1979-2014 (observed), 2015-2035 (projected), ICD-10 C32

Projections are based on observed incidence and mortality rates and therefore implicitly include changes in cancer risk factors, diagnosis and treatment. It is not possible to assess the statistical significance of changes between 2014 (observed) and 2035 (projected) figures. Confidence intervals are not calculated for the projected figures. Projections are by their nature uncertain because unexpected events in future could change the trend. It is not sensible to calculate a boundary of uncertainty around these already uncertain point estimates. Changes are described as "increase" or "decrease" if there is any difference between the point estimates.

Last reviewed:

The lifetime risk of developing laryngeal cancer is around 1 in 175 for men and around 1 in 800 for women, in 2012 in the UK.[1]

The lifetime risk for laryngeal cancer has been calculated to account for the possibility that someone can have more than one diagnosis of laryngeal cancer over the course of their lifetime (‘Adjusted for Multiple Primaries’ (AMP) method).[2]

References

  1. Lifetime risk estimates calculated by the Statistical Information Team at Cancer Research UK. Based on data provided by the Office of National Statistics, ISD Scotland, the Welsh Cancer Intelligence and Surveillance Unit and the Northern Ireland Cancer Registry, on request, December 2013 to July 2014.
  2. Sasieni PD, Shelton J, Ormiston-Smith N, et al. What is the lifetime risk of developing cancer?: The effect of adjusting for multiple primaries. Br J Cancer, 2011. 105(3): p. 460-5.
Last reviewed:

There is evidence for a strong association between laryngeal cancer incidence and deprivation for both males and females in England.[1] England-wide data for 2006-2010 show European age-standardised Open a glossary item incidence rates are 188% higher for males living in the most deprived areas compared with the least deprived, and 288% higher for females.[1]

Laryngeal Cancer (C32), European Age-Standardised Incidence Rates by Deprivation Quintile, England, 2006-2010

The estimated deprivation gradient in laryngeal cancer incidence between people living in the most and least deprived areas in England has not changed in the period 1996-2010.[1] It has been estimated that there would have been around 650 fewer cancer cases each year in England during 2006-2010 if all people experienced the same incidence rates as the least deprived.[1]

Last reviewed:

Prevalence refers to the number of people who have previously received a diagnosis of cancer and who are still alive at a given time point. Some patients will have been cured of their disease and others will not.

Worldwide, it is estimated that there were more than 425,000 men and women still alive in 2008, up to five years after being diagnosed with laryngeal cancer.[1]

References

  1. Ferlay J, Shin HR, Bray F, et al. GLOBOCAN 2008 v1.2, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 [Internet]. Lyon, France: International Agency for Research on Cancer (IARC): 2010. Available from: http://globocan.iarc.fr. Accessed May 2012. 
Last reviewed:

Laryngeal cancer is the 20th most common cancer in Europe, with around 39,900 new cases diagnosed in 2012 (1% of the total). In Europe (2012), the highest World age-standardised Open a glossary item incidence rates for laryngeal cancer are in Hungary for men and Albania for women; the lowest rates are Iceland for both men and women. UK laryngeal cancer incidence rates are estimated to be the 7th lowest in males in Europe, and 15th highest in females.[1] These data are broadly in line with Europe-specific data available elsewhere.[2]

Around 157,000 new cases of laryngeal cancer were diagnosed worldwide in 2012 (1% of the total). Laryngeal cancer incidence rates are highest in the Caribbean and lowest in Western Africa, but this partly reflects varying data quality worldwide.[1]

Variation between countries may reflect different prevalence of risk factors, use of screening and diagnostic methods.

References

  1. Ferlay J, Soerjomataram I, Ervik M, et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr, accessed December 2013.
  2. Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, et al.Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012. European Journal of Cancer (2013) 49, 1374-1403. 
Last reviewed:

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