Laryngeal cancer incidence statistics

Cases

New cases of laryngeal cancer, 2013, UK

 

Proportion of all cases

Percentage laryngeal cancer is of total cancer cases, 2013, UK

 

Age

Age that 6 in 10 of laryngeal cancer cases are diagnosed, 2011-2013, UK

 

Trend since 1970s

Laryngeal cancer incidence rates have changed differently for each sex since the late 1970s, GB

 

Laryngeal cancer accounts for 0.7% of all new cases in the UK (2013); 1% of all male cases, and 0.2% of all female cases.[1-4]

In 2013, there were 2,315 new cases of laryngeal cancer in the UK: 1,915 (83%) in males and 400 (17%) in females, giving a male:female ratio of around 48:10.[1-4] The crude incidence rate Open a glossary item shows that there are 6 new laryngeal cancer cases for every 100,000 males in the UK, and 1 for every 100,000 females.

For both sexes, the European age-standardised incidence rates Open a glossary item (AS rates) are significantly higher in Scotland compared with England.[1-4] Rates do not differ significantly between the other constituent countries of the UK for either sex.

Laryngeal Cancer (C32), Number of New Cases, Crude and European Age-Standardised (AS) Incidence Rates per 100,000 Population, UK, 2013

England Wales Scotland Northern Ireland UK
Male Cases 1,521 114 221 59 1,915
Crude Rate 5.7 7.5 8.5 6.6 6.1
AS Rate 6.8 8.0 9.6 8.1 7.2
AS Rate - 95% LCL 6.5 6.5 8.4 6.1 6.8
AS Rate - 95% UCL 7.2 9.5 10.9 10.2 7.5
Female Cases 290 29 67 14 400
Crude Rate 1.1 1.9 2.4 1.5 1.2
AS Rate 1.1 1.8 2.5 1.7 1.3
AS Rate - 95% LCL 1.0 1.1 1.9 0.8 1.2
AS Rate - 95% UCL 1.3 2.5 3.1 2.6 1.4
Persons Cases 1,811 143 288 73 2,315
Crude Rate 3.4 4.6 5.4 4.0 3.6
AS Rate 3.8 4.7 5.7 4.7 4.0
AS Rate - 95% LCL 3.6 4.0 5.1 3.6 3.8
AS Rate - 95% UCL 3.9 5.5 6.4 5.8 4.2

95% LCL and 95% UCL are the 95% lower and upper confidence limits Open a glossary item around the AS Rate Open a glossary item

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

Laryngeal cancer incidence rates across the former cancer networks throughout the UK vary significantly, with the highest rates in parts of Scotland and northern England, and the lowest rates in southern England.[5]

References

  1. Data were provided by the Office for National Statistics on request, July 2015. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html.
  2. Data were provided by ISD Scotland on request, April 2015. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, February 2015. Similar data can be found here: http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=59080.
  4. Data were provided by the Northern Ireland Cancer Registry on request, March 2015. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.  
  5. Laryngeal cancer (C32) European age-standardised incidence rates by UK Cancer Networks, 2008-2010. These data were extracted from the UK Cancer Information Service, version 4.5b 001, January 2014. 
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Laryngeal cancer incidence is strongly related to age, with the highest incidence rates being in older males and females. In the UK in 2011-2013, on average each year 6 in 10 (60%) cases were diagnosed in people aged 65 and over.[1-4]

Age-specific incidence rates rise from around age 45-49 (sharply in males but more gradually in females), peak in the 70-74 age group in both sexes and subsequently decrease steadily in both sexes, peaking again in males aged 90+. Incidence rates are higher for males than for females aged 40-44 and over (this gap is not significant in younger age groups), and this gap is widest in the 90+ age group, when the male:female incidence ratio of age-specific rates (to account for the different proportions of males to females in each age group) is around 76:10.[1-4]

Laryngeal Cancer (C32), Average Number of New Cases per Year and Age-Specific Incidence Rates, UK, 2011-2013

References

  1. Data were provided by the Office for National Statistics on request, July 2015. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html.
  2. Data were provided by ISD Scotland on request, April 2015. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, February 2015. Similar data can be found here: http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=59080.
  4. Data were provided by the Northern Ireland Cancer Registry on request, March 2015. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.  
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Laryngeal cancer incidence rates have decreased in males and females combined in Great Britain since the late 1970s.[1-3] However this includes a decrease in males and overall stable rates in females, and for both sexes there has been increase followed by a decrease during this time.[1-3]

For males, European age-standardised (AS) Open a glossary item incidence rates increased by 11% between 1979-1981 and 1992-1994, then fell by 24% between 1992-1994 and 2011-2013. The pattern is similar for females, with rates increasing by 17% between 1979-1981 and 1993-1995, then falling by 17% between 1993-1995 and 2011-2013.

Laryngeal Cancer (C32), European Age-Standardised Incidence Rates, Great Britain, 1979-2013

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

Over the last decade in the UK (between 2002-2004 and 2011-2013), larynx cancer AS incidence rates have remained stable in males and females combined, though this includes a decreased for males (7%) and stable rates in females.[1-4]

Laryngeal Cancer (C32), European Age-Standardised Incidence Rates, UK, 1993-2013

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

Larynx cancer incidence trends probably reflect changing prevalence of risk factors, with recent incidence trends influenced by risk factor prevalence in years past.

Laryngeal cancer incidence rates for males in Great Britain were similar in 2011-2013 compared with the late 1970s for those aged 70-79, however this included an increase followed by a decrease in this time.[1-3] Rates have overall decreased in males aged 25-49, 50-59, 60-69 and 80+, though this also includes an increase followed by a decrease. The largest increase was for males aged 70-79, for whom rates increased by 24% between 1979-1981 and 1992-1994, followed by a decrease of 25% between 1992-1994 and 2011-2013.

Laryngeal Cancer (C32), European Age-Standardised Incidence Rates, by Age, Males, Great Britain, 1979-2013

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

Laryngeal cancer European AS incidence rates for females in Great Britain were similar in 2011-2013 compared with the late 1970s for most age groups, though in some age groups this includes an increase followed by a decrease.[1-3] In females aged 70-79, rates increased by 47% between 1979-1981 and 1998-2000, then decreased by 28% between 1998-2000 and 2005-2007, and have since remained stable. In females aged 60-69 rates fluctuated but overall increased by 40% between 1979-1981 and 1988-1990, and subsequently decreased by 25% between 1988-1990 and 2011-2013.[1-3] Rates in females aged 50-59 have decreased by 26% since peaking in 1987-1989.[1-3]

Laryngeal Cancer (C32), European Age-Standardised Incidence Rates, by Age, Females, Great Britain, 1979-2013

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

References

  1. Data were provided by the Office for National Statistics on request, July 2015. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html.
  2. Data were provided by ISD Scotland on request, April 2015. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, February 2015. Similar data can be found here: http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=59080.  
  4. Data were provided by the Northern Ireland Cancer Registry on request, March 2015. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.  
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The lifetime risk of developing laryngeal cancer is around 1 in 175 for men and around 1 in 800 for women, in 2012 in the UK.[1]

The lifetime risk for laryngeal cancer has been calculated to account for the possibility that someone can have more than one diagnosis of laryngeal cancer over the course of their lifetime (‘Adjusted for Multiple Primaries’ (AMP) method).[2]

References

  1. Lifetime risk estimates calculated by the Statistical Information Team at Cancer Research UK. Based on data provided by the Office of National Statistics, ISD Scotland, the Welsh Cancer Intelligence and Surveillance Unit and the Northern Ireland Cancer Registry, on request, December 2013 to July 2014.
  2. Sasieni PD, Shelton J, Ormiston-Smith N, et al. What is the lifetime risk of developing cancer?: The effect of adjusting for multiple primaries. Br J Cancer, 2011. 105(3): p. 460-5.
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There is evidence for a strong association between laryngeal cancer incidence and deprivation for both males and females in England.[1] England-wide data for 2006-2010 show European age-standardised Open a glossary item incidence rates are 188% higher for males living in the most deprived areas compared with the least deprived, and 288% higher for females.[1]

Laryngeal Cancer (C32), European Age-Standardised Incidence Rates by Deprivation Quintile, England, 2006-2010

The estimated deprivation gradient in laryngeal cancer incidence between people living in the most and least deprived areas in England has not changed in the period 1996-2010.[1] It has been estimated that there would have been around 650 fewer cancer cases each year in England during 2006-2010 if all people experienced the same incidence rates as the least deprived.[1]

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Prevalence refers to the number of people who have previously received a diagnosis of cancer and who are still alive at a given time point. Some patients will have been cured of their disease and others will not.

Worldwide, it is estimated that there were more than 425,000 men and women still alive in 2008, up to five years after being diagnosed with laryngeal cancer.[1]

References

  1. Ferlay J, Shin HR, Bray F, et al. GLOBOCAN 2008 v1.2, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 [Internet]. Lyon, France: International Agency for Research on Cancer (IARC): 2010. Available from: http://globocan.iarc.fr. Accessed May 2012. 
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Laryngeal cancer is the 20th most common cancer in Europe, with around 39,900 new cases diagnosed in 2012 (1% of the total). In Europe (2012), the highest World age-standardised Open a glossary item incidence rates for laryngeal cancer are in Hungary for men and Albania for women; the lowest rates are Iceland for both men and women. UK laryngeal cancer incidence rates are estimated to be the 7th lowest in males in Europe, and 15th highest in females.[1] These data are broadly in line with Europe-specific data available elsewhere.[2]

Around 157,000 new cases of laryngeal cancer were diagnosed worldwide in 2012 (1% of the total). Laryngeal cancer incidence rates are highest in the Caribbean and lowest in Western Africa, but this partly reflects varying data quality worldwide.[1]

Variation between countries may reflect different prevalence of risk factors, use of screening and diagnostic methods.

References

  1. Ferlay J, Soerjomataram I, Ervik M, et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr, accessed December 2013.
  2. Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, et al.Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012. European Journal of Cancer (2013) 49, 1374-1403. 
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Cancer Statistics Explained

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