A trial of adavosertib for head and neck cancer (WISTERIA)

Overview

Cancer types:

Head and neck cancers, Laryngeal cancer, Mouth and oropharyngeal cancer

Status:

Results

Phase:

Phase 1

Details

This trial looked at a drug called adavosertib (AZD1775) before surgery and after surgery for head and neck cancer. It was for people who had one of the following head and neck cancers:

mouth (oral) cancer
cancer of the voice box (larynx)
cancer where the food pipe surrounds the voice box (hypopharynx)

Diagram showing the parts of the pharynx.

The trial was open for people to join between 2017 and 2019. The team published the results in 2024.

Recruitment start: 30 October 2017

Recruitment end: 15 July 2019

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Professor Hisham Mehanna

Supported by

AstraZeneca

Cancer Research UK

University of Birmingham

Last reviewed: 18 March 2024

CRUK internal database number: 14313

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