
"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”
This trial is comparing two types of surgery for thyroid cancer. It is comparing removing the whole thyroid with removing only the side (lobe) that the cancer is in.
It is open to people with thyroid cancer that:
The thyroid has 2 lobes.
Doctors use surgery to remove cancer from the thyroid. There are 2 types of surgery that surgeons use:
After a total thyroidectomy you might have radioactive iodine treatment.
You will also need to take hormone therapy for the rest of your life.
This is because your thyroid produces that the body needs to work properly. You may also need to take vitamin D and calcium tablets.
After a lobectomy or hemithyroidectomy you may not need to have hormone therapy. This is because the remaining part should produce enough hormones.
Some people find out they have thyroid cancer by chance. They have problems with their thyroid and have tests or procedures to find out why. One of these procedures might be removing part of their thyroid.
There are 2 groups of people in this trial.
Group 1
This group is for people who had one lobe of their thyroid removed (hemithyroidectomy) because they have had problems with their thyroid. They found out that they have thyroid cancer after surgery.
Group 2
People who have had a thyroid cancer diagnosis before surgery.
The aims of this trial are to find out:
The following bullet points are a summary of the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you.
Who can take part
You may be able to join this trial if you:
And all of the following apply. You:
Who can’t take part
You cannot join this trial if any of these apply. You have:
This is a phase 3 trial. The team need 456 people to join.
The researchers need 2 different groups of people. Which group you are in depends on whether you have already had a hemithyroidectomy or not.
This is a randomised trial. Neither you nor your doctor chooses which treatment group you are in.
There are 2 treatment groups for each group of people. A computer puts you into one of the 2 treatment groups.
Group 1
This is for people who have already had a surgery to remove 1 lobe of the thyroid and then had cancer diagnosed. The treatment groups are:
Group 2
People diagnosed with thyroid cancer before having surgery. You have either:
Your doctor will tell about your surgery and how long you might be in hospital. You have a to have surgery.
After surgery you might have:
Your doctor will talk to you about these if any apply to you.
Quality of life
You fill in 5 questionnaires before having surgery:
The questions ask about:
These are quality of life questionnaires.
Web-based ‘App’ sub study
The team might ask you to take part in an optional sub study.
The sub study looks at using a web-based application (‘app’) to fill in the quality of life questionnaires. If you agree to take part, you can access the web-based app on your mobile phone or tablet. When you are due to complete the questionnaires the app sends you a text (SMS) message alert.
The trial team ask the first 30 to 50 people on the HoT trial to use the ‘app’ as part of a pilot phase. If they agree they will be able to use the app to complete the trial questionnaires.
After this anyone who agrees to take part in the sub study are randomly into 1 of 2 groups. Half of the people:
The aim of the sub study is to find whether using the app is easier and better for people than completing the paper questionnaires.
You don’t have to agree to join the sub study.
You can use the paper version of the questionnaires throughout the trial or you can switch from the web-based app to the paper questionnaires at any time you wish.
You see the doctor for a before joining the trial and before surgery.
People in group 1 not having a second surgery
You have a follow up appointment to see the doctor 6 months after your hemithyroidectomy. And then you see them once a year for up to 6 years.
Follow up for people in groups 1 and 2 having surgery
After surgery you see the doctor 2 to 4 weeks for blood tests and to see how you are. You then see the doctor:
During follow up everyone has these tests:
After 6 years your doctor will tell you how often they need to see you.
The trial team monitor you during treatment and afterwards. Contact your advice line or tell your doctor or nurse if any side effects are bad or not getting better.
The most common side effects of having thyroid surgery include:
We have information about thyroid surgery.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor Dae Kim
University College London (UCL)
National Institute for Health Research (NIHR)
Butterfly Thyroid Cancer Trust Charity
Thyroid Cancer Support Group Wales
University College London Clinical Trials Centre (UCL-CTC)
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If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”