A trial of GSK2256098 for solid tumours

This trial is looking at a drug called GSK2256098 for people who have a solid tumour that is not responding to other treatment. A solid tumour is any type of cancer, except for leukaemia or lymphoma.

Some types of cancer produce high levels of a protein called focal adhesion kinase or FAK. FAK plays a role in the way cancer grows and spreads. Blocking it may stop cancer spreading.

In this trial, researchers are looking at a drug called GSK2256098 which can block FAK. It is known as a FAK inhibitor.

The aims of this trial are to find out

• The highest dose of GSK2256098 you can have safely

• What the side effects are

• How much of the drug gets into the bloodstream and how long your body takes to get rid of it

• If there is something about your cancer that makes it more or less likely to respond to the drug