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A study of alpelisib and hormone therapy for advanced breast cancer (BYLieve)

Overview

Cancer types:

Breast cancer, Secondary cancers

Status:

Closed

Phase:

Phase 2

Details

This study is looking at alpelisib with either fulvestrant or letrozole for advanced breast cancer that has continued to grow.

It is for men and women whose breast cancer has spread into surrounding tissue (is locally advanced) or elsewhere in the body. And whose breast cancer cells have:

  • receptors for oestrogen or progesterone (is hormone receptor positive)

  • low or no amounts of (this is called HER2 negative breast cancer)

  • a change to the PIK3CA gene

Recruitment start: 1 January 2018

Recruitment end: 30 September 2020

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Prof Nick Turner

Supported by

Novartis

Last reviewed: 29 September 2020

CRUK internal database number: 15219

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