A trial looking at radiotherapy with erlotinib for lung cancer that has spread to the brain (TACTIC)

Cancer type:

Cancer spread to the brain
Lung cancer
Non small cell lung cancer
Secondary cancers




Phase 2

This study looked at radiotherapy to the brain alongside a drug called erlotinib for non small cell lung cancer (NSCLC) that had spread to the brain. This trial was supported by Cancer Research UK.

If lung cancer spreads to the brain (secondary brain cancer), doctors may suggest treatment with radiotherapy to shrink the cancer and help control it. Doctors were keen to find out if combining radiotherapy with erlotinib (also known as Tarceva) improves this treatment.

Erlotinib is a type of biological therapy. It is a cancer growth blocker. It stops signals that cancer cells use to divide and grow.

The aims of the trial were to find out

  • If erlotinib combined with radiotherapy to the brain works better than radiotherapy on its own
  • More about the side effects
  • More about quality of life

Summary of results

The trial team found that having erlotinib alongside radiotherapy to the brain is not a useful treatment for non small lung cancer (NSCLC) that has spread to the brain. They also found that most people who took part did not have a specific change (EGFR mutation) in a lung cancer gene.

80 people with NSCLC that had recently spread to more than one area of the brain took part in this trial and,

  • Half had radiotherapy to the brain and erlotinib tablets
  • Half had radiotherapy to the brain and dummy tablets (placebo)

When radiotherapy finished, everybody continued taking erlotinib or the dummy drug to try and keep the cancer under control for longer. Doctors call this maintenance treatment.

A planned review of the results was done after the first 80 patients were recruited to decide if more people should take part.  When the researchers looked at the results, they found that the treatment hadn’t worked as well as they had hoped in enough patients. So, as planned, no more patients were recruited.

The trial team published their results in 2014.They followed up the people who took part for an average of one year after treatment. They looked at

  • How long it was before the brain cancer got worse
  • How long people lived for after treatment
  • How treatment affected their quality of life

The researchers found no difference between the 2 groups in any of these. So, adding erlotinib was no more help than the standard treatment of radiotherapy alone to the brain.

The researchers found that erlotinb with radiotherapy was safe to give and the side effects were mild. The worst side effects reported from those having erlotinib were a skin rash and tiredness (fatigue).

Although erlotinib and radiotherapy didn’t appear to work for this group of patients, the researchers suggest that it should be looked at in future trials for people with a specific change (EGFR mutation) in a lung cancer gene.  

We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists (peer reviewed Open a glossary item) and published in a medical journal. The figures we quote above were provided by the trial team. We have not analysed the data ourselves.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Siow Ming Lee

Supported by

Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
University College London (UCL)

Other information

This is Cancer Research UK trial number CRUK/05/034.

If you have questions about the trial please contact our cancer information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 706

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Around 1 in 5 people take part in clinical trials

3 phases of trials

Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.

Last reviewed:

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