A trial of radiotherapy and targeted treatment for non small cell lung cancer (CONCORDE)

The following bullet points are a summary of the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you. 

Please note, there are several treatment groups so the entry conditions for this trial are complex. Each group has specific entry conditions and we haven’t listed them all.

Who can take part

You may be able to join this trial if all of the following apply. 
You:

• have non small cell lung cancer
• have lung cancer that hasn’t spread outside the chest (stage 2B or stage 3)
• aren’t suitable to have surgery or a combination of chemotherapy and radiotherapy (chemoradiotherapy)
• are due to have radiotherapy with the aim to cure as part of your treatment plan (you may or may not be having chemotherapy before the radiotherapy)
• are suitable to have high doses of radiotherapy (radical radiotherapy)
• might have had chemotherapy recently but it was within 10 weeks of starting radiotherapy
• have satisfactory blood test results 
• don’t have any breathlessness when walking on level ground but you might have some, for example when hurrying up a slight hill
• can care for yourself but can't carry on with all your normal activities or do active work (Karnofsky Performance status of 70 or more)
• are willing to use reliable contraception during the trial and for a period after if there is any chance you or your partner could become pregnant 
• are at least 18 years old

Who can’t take part

Cancer related
You cannot join this trial if any of these apply. You:

• have a mix of non small cell and small cell lung cancer 
• have NSCLC that got worse after your first chemotherapy (induction chemotherapy) if you have had chemotherapy
• had a lung function test  that showed your lungs aren’t working well
• have taken part in a clinical trial or study of a treatment or device within 4 weeks of starting treatment
• have any other cancer that might affect you taking part in the trial 

Medical conditions
You cannot join this trial if any of these apply. You:

• have had radiotherapy to the chest in the past unless you had it for breast cancer and the overlap of the breast  and lung cancer treatment area is small 
• have had treatment that affects the lungs such as busulfan or bleomycin, within the past year. If you had this treatment a long time ago you might be able to join if it didn’t affect your lungs. And if you had drugs called nitrosoureas  such as carmustine or lomustine in the year before joining the trial. You might be able to take part if the treatment didn’t affect your lungs.
• have a condition that affects the lungs called interstitial pneumonitis
• have had a stem cell transplant  with your own cells or somebody else’s or you have had an organ transplant  for example a liver or lung transplant
• can’t swallow tablets or you have a problem with your gut that means you can’t absorb the medication
• have an abnormal heart rhythm called QT prolongation
• have a heart problem such as a heart attack in the last 4 months or high blood pressure that isn’t well controlled with medication
• have a problem with bleeding that is ongoing
• have moderate to severe numbness or tingling in your hands or feet
• have HIV
• have an active hepatitis B or hepatitis C infection
• have moderate to severe side effects from treatment apart from hair loss
• have myelodysplastic syndrome  or acute myeloid leukaemia  or you have symptoms that suggest you might have either
• have had major surgery within 2 weeks of finding out you are suitable to take part in the trial 
• have had a chemotherapy drug called gemcitabine within 6 months of joining the trial
• have severe fits (seizures)
• have an autoimmune disease . This is apart from having white patches on your skin (vitiligo), type 1 diabetes, hair loss (alopecia), thyroid  problems that are controlled by medications, a skin condition that doesn’t need treatment or coeliac disease controlled by diet. You might be able to take part if you haven’t had an active autoimmune disease in the last 5 years.
• have any other medical condition or mental health problem that might affect you taking part in the trial. For example you have an active COVID-19 infection.

Other 
You cannot join this trial if you are pregnant or breastfeeding.

As well as the above there are specific entry conditions and exclusion criteria for each treatment group. Speak to your doctor or research nurse if you want to find out more about the entry conditions for this trial.