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A trial of encorafenib and binimetinib for melanoma that has spread (PREMIUM)

Overview

Cancer types:

Melanoma, Secondary cancers, Skin cancer

Status:

Closed

Phase:

Phase 2

Details

This trial is looking at 2 drugs called encorafenib and binimetinib before and after surgery for melanoma.

It is for people:

  • whose melanoma has spread to the or other parts of the body

  • who can have surgery to completely remove the melanoma

  • who have melanoma with a change in the BRAF gene

Recruitment start: 27 February 2023

Recruitment end: 31 October 2025

How to join

Please note: In order to you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Dr Pippa Corrie

Supported by

Cambridge University Hospitals NHS Foundation Trust

Cambridge Clinical Trials Unit - Cancer Theme

Pierre Fabre Ltd, UK

Last reviewed: 12 Aug 2025

CRUK internal database number: 17884

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