“I think it’s really important that people keep signing up to these type of trials to push research forward.”
A trial of a vaccine called AST-VAC2 for non small cell lung cancer
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
More about this trial
- find out how safe treatment is
- find out if the vaccine stimulates the immune cells
- learn more about the side effects
Who can enter
The following bullet points list the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you.
Who can take part
- have non small cell lung cancer that has spread elsewhere in the body and there isn’t a suitable standard treatment available
- have cancer that the doctor can measure on a scan
- have cancer that it might be possible to take tissue samples from
- haven’t had chemotherapy in the last 4 weeks, an experimental treatment in the last 6 weeks or immunotherapy in the last 8 weeks
- have large amounts of certain type of HLA protein
- are well enough to have 6 vaccinations
- are well enough to be up and about for at least half the day (performance status 0, 1 or 2)
- have satisfactory blood test results
- are willing to use reliable contraception during treatment and for 6 months afterwards if there is any chance that you or your partner could become pregnant
- have had radiotherapy unless it was for symptom control such as pain in the 4 weeks before starting treatment
- have side effects from past treatments unless they are mild apart from hair loss
- are having steroids unless it is replacement treatment, a cream or an inhaler or another treatment that dampens down your immune system
- haven’t fully recovered from major surgery to your chest or tummy (abdomen)
- have an active infection that needs treatment
- have an autoimmune condition
- have congestive heart failure, an abnormal rhythm of the heart, narrowed arteries in the heart or any other significant heart problem
- are having an experimental treatment as part of another clinical trial
- have a condition that might interfere with how your immune system works
- have hepatitis B or hepatitis C
- have HIV
- have any other medical condition that the trial team think could affect you taking part
- have had a vaccination within 4 weeks of having AST-VAC2. Please note that the current approved COVID-19 vaccines are allowed.
The trial team will ask to take some extra tissue samples, blood samples and samples of skin.
You give the tissue samples (
You give the blood samples at the same time as your routine blood tests if possible. The trial team will give you more information about the specific timings of these tests.
They will also ask to take a sample of skin (a skin biopsy). Your doctor will have a look at the area where you had the injections to see if you have had a reaction (or an inflammatory response). The doctor will ask to take a skin biopsy if the area is red inflamed or swollen. They plan to take up to 3 skin biopsies.
The researchers plan to use the samples to understand how AST-VAC2 works.
- a reaction at the injection site such as redness or swelling
- an allergic reaction
- tiredness (fatigue)
- muscle aches
- low temperature
- an overreaction of the immune system causing high temperatures, chills and a fast pulse
- abnormal cell growth resulting in a lump under the skin
How to join a clinical trial
Prof Christian Ottensmeier
Professor Gary Middleton
Cancer Research UK
This is Cancer Research UK trial number CRUKD/17/003.