The women taking part were put into 1 of 3 treatment groups at
random. Neither they nor their doctor could decide which group they were in, and:
- 522 women had both carboplatin and paclitaxel once every 3 weeks (group A)
- 523 women had carboplatin once every 3 weeks, and paclitaxel once a week (group B)
- 521 women had both carboplatin and paclitaxel once a week (group C)
The research team looked at how well the different treatment plans worked.
First they looked at how long it was until the cancer started to grow. They found it was similar in the 3 groups:
- 24.4 months for those in group A (3 weekly chemotherapy)
- 24.9 months for those in group B (3 weekly carboplatin and weekly paclitaxel)
- 25.3 months for those in group C (weekly chemotherapy)
When they looked at how many women were living 2 years after joining the trial, they found this was also similar in the 3 groups:
- 8 out of 10 (80%) of those in group A
- just over 8 out of 10 (82%) of those in group B
- just under 8 out of 10 (78%) of those in group C
They also looked at the side effects. A few more women who had weekly chemotherapy in groups B and C had side effects, compared to the women in group A. The most common additional side effect was a drop in white blood cells. The number of women with other side effects was similar in the 3 groups.
The research team concluded that weekly chemotherapy was safe to give, but didn’t work better than 3 weekly chemotherapy as a first treatment for ovarian cancer. They suggest that carboplatin and paclitaxel every 3 weeks should still be the standard treatment for these women.
We have based this summary on information from the research team. The information they sent us has been reviewed by independent specialists (
peer reviewed 
) but may not have been published in a medical journal. The figures we quote above were provided by the research team. We have not analysed the data ourselves.