Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.
A trial looking at radiotherapy and chemotherapy after surgery in women with womb (endometrial) cancer (PORTEC 3)
This trial compared radiotherapy on its own with radiotherapy and chemotherapy in women with womb (endometrial) cancer. This trial was supported by Cancer Research UK.
More about this trial
- find out if it’s better to have chemoradiotherapy or radiotherapy on its own after surgery for womb
- learn more about the side effects of these treatments and how they affect quality of life
Summary of results
- Group 1 – women had radiotherapy on its own
- Group 2 – women had chemoradiotherapy followed by more chemotherapy
All women had external radiotherapy to their pelvic area. They had this once a day from Monday to Friday over about 6 weeks. Some women also had internal radiotherapy if cancer cells had been found in their cervix.
- 330 women had radiotherapy
- 330 women had chemoradiotherapy followed by more chemotherapy
- 255 out of the 330 women (nearly 77%) in the radiotherapy group
- 269 out of the 330 women (nearly 82%) in the chemoradiotherapy group
- 227 women (nearly 69%) in the radiotherapy only group
- 247 women (nearly 76%) in the chemoradiotherapy group
- 41 women (12%) in the radiotherapy only group
- 198 women (60%) in the chemoradiotherapy group
- tiredness (fatigue)
- feeling or being sick
- tingling or numbness due to nerve changes
- muscle or joint pain
- hair loss
- 1 woman in the radiotherapy group
- 20 women (8%) in the chemoradiotherapy group
- stage 1 and 2 womb cancer
- stage 3 cancer
How to join a clinical trial
Dr M. Powell
Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
This is Cancer Research UK trial number CRUK/08/001.