Last year in the UK over 60,000 cancer patients enrolled on clinical trials aimed at improving cancer treatments and making them available to all.
A trial looking at radiotherapy and chemotherapy after surgery in women with womb (endometrial) cancer (PORTEC 3)
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This trial compared radiotherapy on its own with radiotherapy and chemotherapy in women with womb (endometrial) cancer. This trial was supported by Cancer Research UK.
More about this trial
- find out if it’s better to have chemoradiotherapy or radiotherapy on its own after surgery for womb
- learn more about the side effects of these treatments and how they affect quality of life
Summary of results
- Group 1 – women had radiotherapy on its own
- Group 2 – women had chemoradiotherapy followed by more chemotherapy
All women had external radiotherapy to their pelvic area. They had this once a day from Monday to Friday over about 6 weeks. Some women also had internal radiotherapy if cancer cells had been found in their cervix.
- 330 women had radiotherapy
- 330 women had chemoradiotherapy followed by more chemotherapy
- 255 out of the 330 women (nearly 77%) in the radiotherapy group
- 269 out of the 330 women (nearly 82%) in the chemoradiotherapy group
- 227 women (nearly 69%) in the radiotherapy only group
- 247 women (nearly 76%) in the chemoradiotherapy group
- 41 women (12%) in the radiotherapy only group
- 198 women (60%) in the chemoradiotherapy group
- tiredness (fatigue)
- feeling or being sick
- tingling or numbness due to nerve changes
- muscle or joint pain
- hair loss
- 1 woman in the radiotherapy group
- 20 women (8%) in the chemoradiotherapy group
- stage 1 and 2 womb cancer
- stage 3 cancer
How to join a clinical trial
Dr M. Powell
Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
This is Cancer Research UK trial number CRUK/08/001.